A Digital Twin of Flexible Modular Continuous API Manufacturing Process
- Type: Conference Presentation
- Conference Type: AIChE Annual Meeting
- Presentation Date: November 9, 2021
- Duration: 24 minutes
- Skill Level: Intermediate
- PDHs: 0.50
In this work, a digital twin for continuous APIs manufacturing process using modular components has been demonstrated. The process flowsheet model is the heart of 'digital twin' and consists of mathematical representation of three modules with the options of adding more as needed. The first module is for feeding and dispensing. It consists of a refill unit, feed tank, pump, mixing, and preheater. The second module is for performing the chemical reactions required to produce the target APIs. This module consists of tubular reactors placed inside a heating and cooling jacket. The third module is focused on separation of API from impurities. A continuous chromatographic model is currently used for separation purposes that can be easily replaced with any other type of separation techniques such as continuous crystallization. The applications of the digital twin have been demonstrated for design and development of suitable control architecture for a continuous APIs manufacturing process. The developed control architecture is also modular in nature and can be easily adapted for different manufacturing processes of APIs that may have different material and information flows, dead time variations, and tuning parameters. The proposed digital twin can save the time and resources needed for continuous APIs manufacturing and improve the product quality significantly.
The objective of this presentation is two-fold; first to highlight the developed digital twin and then demonstrate its application for design of process and control architecture of continuous API manufacturing processes.
|AIChE Member Credits||0.5|
|AIChE Graduate Student Members||Free|
|AIChE Undergraduate Student Members||Free|