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  1. An Integrated PAT Approach for a Lab Scale Bioreactor IgG3 Cell Culture Process Real Time Monitoring: A Feasibility Study

    Conference Presentation | AIChE Academy | Nov 6, 2013
    Forum Huiquan Wu A model mAb IgG3 cell culture process real time monitoring scheme was reported in this ... characterization tools for a bioreactor cell culture process understanding. Both inline NIR and FTIR Spectroscopy ... were used to monitor various stages of a model mAb IgG3 cell culture process in real time. In-process ...

  2. An Integrated Systematic Framework to Assist the Development of Pharmaceutical Processes

    Conference Presentation | AIChE Academy | Nov 17, 2014
    processes. Emmanouil Papadakis, Gürkan Sin, Krist V.Gernaey, Rafiqul Gani* CAPEC-PROCESS- Department of ... dominated by batch wise processes, which have served well the pharmaceutical industries as well as the ... a multipurpose plant. However, batch processes may not be very efficient for product quality assurance and may ...

  3. Chemical Engineering in the Pharmaceutical Industry: R&D to Manufacturing

    Book | AIChE | The Global Home of Chemical Engineers | Oct 1, 2010
    deals with various unique elements in the drug development process within chemical engineering science ... experimental methods related to pharmaceutical process development are learned on the job. This book is ... strategies for regulatory filings. For the current professionals, in-silico process modeling tools that ...

  4. Applying PAT for Pharmaceutical Powder Blending Process: Challenges and Opportunities

    Conference Presentation | AIChE Academy | Nov 19, 2014
    powder blending can help to achieve different levels of process understanding, such as real-time process ... monitoring and fault detection, process control strategies to ensure final product quality, or multivariate ... experimental errors associated with sampling practice, dynamic process environment, dynamic measurement ...

  7. Implementing a Flexible Recipe Management Strategy for Development of Biopharmaceuticals

    Conference Presentation | AIChE Academy | Nov 6, 2013
    Forum Alison Harkins Optimizing the process of developing novel biopharmaceutical products is an area of ... that process is defining flexible standards through which we communicate our processes and associated ... diverse number of systems and processes that must adopt the recipe structure including API production and ...

  9. Plant-Wide Hybrid Model Predictive Control of a Continuous Pharmaceutical Tablet Manufacturing Process Via Direct Compaction

    Conference Presentation | AIChE Academy | Oct 29, 2012
    be manufactured through continuous processing integrated with online monitoring tools coupled with ... efficient automatic model-based feedback control system to achieve the precise control of process variables ... process considered in this study is highly interactive, nonlinear, and has time delays due to sensor ...

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