Systems Biology: Open Challenges and Opportunities for Chemical Engineers

Originally delivered Jan 20, 2009
Source: AIChE
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Systems biology involves the analysis of multiple scales of 'control' in biological networks, from the regulation of gene transcription to the homeostatic regulation of metabolism in the whole body. These natural control circuits are paragons of optimality: over millennia, they have been honed to achieve robust regulation of a myriad of processes at the levels of genes, proteins, cells, and entire systems. However, these architectures can be compromised, leading to 'failure' in the circuit, and the ensuing disease state. By taking an integrative or systems viewpoint, in both experimental and modeling approaches, there is promise of increased understanding that can lead to novel approaches for therapeutics and drug discovery. This presentation will demonstrate the role of chemical engineers in systems biology, and show how they help to meet biomedical challenges.


Francis J. Doyle III

Francis J. Doyle III serves as Dean of the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS).

Doyle, who is also the John A. and Elizabeth Armstrong Professor of Engineering & Applied Sciences, was elected to the National Academy of Engineering (NAE) for his insights into natural biological control systems and innovative engineering of diabetes control devices. As co-principal investigator of the artificial pancreas project, Doyle leads a multidisciplinary team of engineers and scientists who are developing algorithms to automate an insulin delivery...Read more

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