Proteins, Pathways and Genomes: Innovations in Forward Engineering
- Type: Archived Webinar
- Level: Basic
- Duration: 1 hour
- PDHs: 0.00
The development of CRISPR systems to facilitate the editing of genomes has created great excitement and inspired new ideas in engineering biology. While transformative, first-generation CRISPR technologies remain limited across multiple important dimensions including scalability, genomic accessibility, variety of modifications, and ease of use.
Lysine, predominately used as an animal feed supplement, is a multi-billion-dollar industry however supply is limited due to the cost of current production methods. This webinar will share case studies how Inscripta leveraged its new CRISPR-based technology to design, generate, and screen libraries totaling > 200,000 single edits to improve lysine production in E. coli. Dozens of beneficial edits across the entire genome were discovered to accelerate the Design-Generate-Test-Learn cycle and increase the lysine production by 14,000-fold - ushering in the next era of genome editing.
Attend this webinar to:
- Review the Lysine production improvement data
- Learn how to significantly speed up the DGTL cycle
- Obtain engineering microbial strain at a speed never reach before
- Learn about Inscripta’s Onyx microbial benchtop digital genome editing platform
- Understand a typical workflow on the Onyx Platform
Dr. Eric Abbate serves as the Director of Analytical Biochemistry on the Applications Development team. His work primarily focuses on developing and utilizing high-throughput phenotyping workflows to screen libraries generated using the Onyx platform.
Eric’s academic background is in protein structure/function and worked for many years developing enzymes for industrial use at Novozymes prior to joining Inscripta.Read more
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