Molecular Bioprocessing as a New Paradigm for Drug Discovery Originally delivered Mar 2, 2010 Developed by: SBE - Society for Biological Engineering Type: Archived WebinarLevel: Advanced PDHs: 1.00 Share This Post: Preview Webinar: The drug discovery process is expensive and often inefficient. With the emergence of genomic and proteomic information, the growth of critical molecular targets is rapid. Nevertheless, the development of active, selective, and safe drug candidates (small molecule or biopharmaceutical) has not kept pace with such advances. For small molecules, a core problem is the lack of high-throughput and accurate methodologies for ADME/Tox, which forces comprehensive toxicology studies to be performed only on later stage lead compounds and preclinical candidates. For biopharmaceuticals, the ability to accurately reproduce the human protein with correct posttranslational modification is limited by lack of knowledge of cellular machinery and then the efficient scale up of protein production and purification. Professor Dordick will detail his research in the design and optimization of high-throughput, microscale discovery and development platforms and the emergence of using bioprocessing strategies at early stages of drug discovery. Presenter(s): Jonathan Dordick Jonathan S. Dordick is the Howard P. Isermann Professor of Chemical and Biological Engineering at VP President for Research. Prof. Dordick received his B.A. in Biochemistry and Chemistry from Brandeis University and his Ph.D. in Biochemical Engineering from MIT. He has held chemical engineering faculty appointments at the University of Iowa, where he also served as the Associate Director of the Center for Biocatalysis and Bioprocessing, and RPI (1998-present) where he also holds joint appointments in the departments of Biomedical Engineering, Materials Science and Engineering, and Biology...Read more Once the content has been viewed and you have attested to it, you will be able to download and print a certificate for PDH credits. If you have already viewed this content, please click here to login. Checkout Checkout Do you already own this? Log In for instructions on accessing this content. Pricing AIChE Member Credits 1 AIChE Members $69.00 AIChE Undergraduate Student Members Free AIChE Graduate Student Members Free SBE Members Free Non-Members $99.00 Webinar content is available with the kind permission of the author(s) solely for the purpose of furthering AIChE’s mission to educate, inform and improve the practice of professional chemical engineering. All other uses are forbidden without the express consent of the author(s).