Modular Biocatalysis Originally delivered Jun 29, 2010 Developed by: SBE - Society for Biological Engineering Type: Archived WebinarLevel: Advanced Duration: 1 hour PDHs: 1.00 Share This Post: Preview Webinar: Modularity is a highly sought after feature in engineering design. A modular catalyst is a multi-component system whose parts can be predictably interchanged for functional flexibility and variety. Over the past two decades, much of the research in our laboratory has focused on understanding the modularity of a of multifunctional enzymes called polyketide synthases (PKSs). PKSs catalyze the biosynthesis of a broad range of complex natural products in microorganisms, including many well-known and emerging antibiotics. A better understanding of the fundamental principles governing their modular chemistry promises to create powerful opportunities for engineering new medicines, and may even open the door to radically new catalytic processes for functionally dense, chiral synthons. Presenter(s): Chaitan Khosla Research interests in this laboratory lie at the interface between chemistry and biology. Assembly line enzymes such as polyketide synthases have extraordinary potential for the programmable biosynthesis of complex natural products. Our laboratory seeks to understand the mechanistic logic of assembly line polyketide synthases, and to harness these insights in order to engineer new antibiotics. The prototypical system of interest to us is the 6-deoxyerythronolide B synthase, which synthesizes the macrocyclic core of erythromycin. Other examples of antibiotic biosynthetic pathways under...Read more Once the content has been viewed and you have attested to it, you will be able to download and print a certificate for PDH credits. If you have already viewed this content, please click here to login. Checkout Checkout Do you already own this? Log In for instructions on accessing this content. Pricing AIChE Member Credits 1 AIChE Members $69.00 AIChE Undergraduate Student Members Free AIChE Graduate Student Members Free SBE Members Free Non-Members $99.00 Webinar content is available with the kind permission of the author(s) solely for the purpose of furthering AIChE’s mission to educate, inform and improve the practice of professional chemical engineering. All other uses are forbidden without the express consent of the author(s).