Cybernetic Approach to Metabolic Modeling

Originally delivered Mar 10, 2011
  • Type:
    Archived Webinar
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  • Duration:
    1 hour
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Cybernetic modeling has evolved for well over two decades. This seminar seeks to: (i) introduce its basic tenets, (ii) expound its relationship to other approaches to modeling metabolism, and (iii) to reveal its unique dynamic capabilities. The framework is shown to provide eloquent support for goal-oriented explanations of regulatory biological phenomena within the cause-and-effect methodology of science through experimental conformation of exacting predictions. It is further shown that relatively sparse dynamic data on wild-type strains suffice to predict the dynamic behavior of numerous gene knockout mutant strains providing a promising framework for metabolic engineering with the focus on productivity of targeted products.

Doraiswami Ramkrishna

Doraiswami (Ramki) Ramkrishna, obtained his B.Chem Eng. in 1960 from BUDCT (now ICT). He received his PhD in 1965 from the University of Minnesota and returned to India to join the IIT Kanpur faculty in 1967. In 1974, he returned to the United States and after visiting appointments at Wisconsin and Minnesota, joined Purdue University in 1976 as Professor. In 1994, he was appointed H.C. Peffer Distinguished Professor. Ramkrishna is noted for his research on the application of mathematics to chemical and biochemical reaction engineering, biotechnology, particulate systems, stochastic...Read more

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