A Bottom Up Approach to Systems Biotechnology – Lessons Learned from Bacterial Signal Transduction Originally delivered Dec 8, 2009 Developed by: SBE - Society for Biological Engineering Type: Archived WebinarLevel: Advanced Duration: 1 hour PDHs: 1.00 Share This Post: Preview Webinar: Bacterial quorum sensing offers an interesting viewpoint from which to study and control cell phenotype. Through the perception of signal molecules (e.g., AHL, AI-2) and their transduction, bacteria coordinate their behavior and act as multicellular units. This coordination is responsible for establishing virulence among a variety of pathogens. A combination of negative (auto-regulation) and positive feedback mechanisms that control the flow of information can be examined by separating the network architecture into sub-networks. Biofabricated devices that report on signaling events are constructed to elucidate cell-cell communication and serve as a foundation upon which to develop new drugs and/or screen for pathogenic phenotype. Using bottom up approaches such as those we have developed will improve our chances to sense and intercept communication in pathogenic bacteria and prevent the spread of infectious diseases. Presenter(s): William E. Bentley William E. Bentley is the Robert E. Fischell Distinguished Professor of Engineering and founding Chair of the Fischell Department of Bioengineering. He is also appointed in the Department of Chemical and Biomolecular Engineering at the University of Maryland, College Park and the Center for Biosystems Research of the University of Maryland Biotechnology Institute.Read more Once the content has been viewed and you have attested to it, you will be able to download and print a certificate for PDH credits. If you have already viewed this content, please click here to login. Checkout Checkout Do you already own this? Log In for instructions on accessing this content. Pricing AIChE Member Credits 1 AIChE Members $69.00 AIChE Undergraduate Student Members Free AIChE Graduate Student Members Free SBE Members Free Non-Members $99.00 Webinar content is available with the kind permission of the author(s) solely for the purpose of furthering AIChE’s mission to educate, inform and improve the practice of professional chemical engineering. All other uses are forbidden without the express consent of the author(s).