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Using Systems Biology for Identification of Novel Metabolic Engineering Targets

  • Type:
    Conference Presentation
  • Conference Type:
    Metabolic Engineering Conference
  • Presentation Date:
    June 17, 2014
  • Duration:
    30 minutes
  • Skill Level:

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The yeast Saccharomyces cerevisiae is widely used for production of fuels, chemicals, pharmaceuticals and materials. Through metabolic engineering of this yeast a number of novel new industrial processes have been developed over the last 10 years. Besides its wide industrial use, S. cerevisiae serves as an eukaryal model organism, and many systems biology tools have therefore been developed for this organism.

Despite our extensive knowledge of yeast metabolism and its regulation we are still facing challenges when we want to engineer complex traits, such as improved tolerance to toxic metabolites like butanol and elevated temperatures or when we want to engineer the highly complex protein secretory pathway. In this presentation it will be demonstrated how we can combine directed evolution with systems biology analysis to identify novel targets for rational design-build-test of yeast strains that have improved phenotypic properties. Examples will be on identifying targets for improving tolerance towards butanol and increased temperature and for improving secretion of heterologous proteins.


Jens Nielsen

Jens Nielsen has received numerous Danish and international awards including the Villum Kann Rasmussen’s Årslegat, Merck Award for Metabolic Engineering, Amgen Award for Biochemical Engineering, Nature Mentor Award, the Gaden Award, the Norblad-Ekstrand gold medal, the Novozymes Prize, the ENI Award and the Eric and Sheila Samson Prize. He is member of several academies, including the National Academy of Engineering and National Academy of Sciences in USA, the Royal Swedish Academy of Science, the Royal Danish Academy of Science and Letters, the Royal Swedish Academy of Engineering Sciences and the American Academy of Microbiology. He is a founding president of the International Metabolic Engineering Society.Read more