Academy Offers

Get a 20% discount on eLearning course purchases made through July 31. Use code ACADEMY20 at check out.

Through June 30, AIChE members will receive complimentary, unlimited access to live and on-demand AIChE webinars by purchasing them with their newly increased number of credits. See more resources.

The Role of PAT, Condition Monitoring and Adaptive Control in Delivering QbD

Source: AIChE
  • Type:
    Conference Presentation
  • Conference Type:
    AIChE Annual Meeting
  • Presentation Date:
    October 29, 2012
  • Duration:
    30 minutes
  • Skill Level:
  • PDHs:

Share This Post:

“The Role of PAT, Condition Monitoring and Adaptive Control in Delivering QbD”

 Stephen Hammond, Mark Smith, Pfizer Global Supply, Peapack NJ, USA

 The use of spectroscopic techniques such as NIR spectroscopy to deliver greater process understanding, either providing difficult to obtain compositional data or more data across a process has been a key factor in the expansion of QbD. The potential for condition monitoring of a unit operation in real-time during the manufacturing process adds enormously to the ability to understand, and reduce the risk of any unit operation.

 This talk will describe the spectroscopic techniques used to assess the process during qualification, and the measurements applied to develop a RtR filing for a low dose product. The RTR approach has been approved in Europe and by FDA. Also in many other countries around the world.

 The future state of QbD will be proposed, where modeling and control based on optimum process trajectories can be effective in reducing variation due to ingredients or processing equipment, that effects the economics of producing product.

Once the content has been viewed and you have attested to it, you will be able to download and print a certificate for PDH credits. If you have already viewed this content, please click here to login.



Do you already own this?



AIChE Member Credits 0.5
AIChE Members $15.00
AIChE Graduate Student Members Free
AIChE Undergraduate Student Members Free
Non-Members $25.00