Optical Coherence Tomography: A New PAT-Tool for Fast and Non-Destructive Analysis of Tablet Coating Quality
- Type: Conference Presentation
- Conference Type: AIChE Annual Meeting
- Presentation Date: October 18, 2011
- Duration: 30 minutes
- Skill Level: Intermediate
- PDHs: 0.50
In this work, high-speed spectral domain OCT was demonstrated as a new Process Analytical Process (PAT) tool for the characterization of pharmaceutical tablet coatings . A Design of Experiments (DoE) was created to produce tablet batches with three coating process parameters. The coating thickness was determined via conventional testings with a µm-caliper or weight gain measurements and compared with OCT measurments. In addition, the results were related to investigations carried out with already established PAT tools like Near-Infrared (NIR) and Raman spectroscopy combined with qualitative and quantitative Multivariate Data Analysis (MVDA).
Finally, the influence of process parameters on the dissolution behavior as a critical quality attribute for the tablets was related to the disintegration times of the tablets for response surface modelling.
 Mauritz JMA, Morrisby RS, Hutton RS, Legge CH, Kaminski CF 2010. Imaging Pharmaceutical Tablets with Optical Coherence Tomography. Journal of Pharmaceutical Sciences 99(1):385-391.
 Koller DM, Hannesschläger G, Leitner M, Khinast JG. Non-Destructive Analysis of Tablet Coatings with Optical Coherence Tomography. European Journal of Pharmaceutical Sciences. 2011.
|AIChE Member Credits||0.5|
|AIChE Graduate Student Members||Free|
|AIChE Undergraduate Student Members||Free|