Maneuvering Around Liquid-Liquid Phase Separation (LLPS) to Enable Development of Robust Crystallization Processes.
- Type: Conference Presentation
- Conference Type: AIChE Annual Meeting
- Presentation Date: November 19, 2020
- Duration: 18 minutes
- Skill Level: Intermediate
- PDHs: 0.30
In this presentation, we detail a methodology to develop a hybrid anti-solvent / cooling crystallization process maneuvering around the LLPS boundaries. Use of automated Lab reactors (ALR) equipped with Process Analytical Technologies (PAT) is highlighted for performing data-rich experiments quickly. The generated data is further modelled with thermodynamic equations for enhanced process understanding. Finally, we will present a case study to showcase how the above-referenced methodology was utilized for enhanced process understanding and for development of a robust and scalable crystallization process.
All authors are employees of AbbVie and may own AbbVie stock. AbbVie sponsored and funded the study; contributed to the design; participated in the collection, analysis, and interpretation of data, and in writing, reviewing, and approval of the final publication.
|AIChE Member Credits||0.5|
|AIChE Graduate Student Members||Free|
|AIChE Undergraduate Student Members||Free|