Cellulosic Ethanol Production through Chemical Detoxification Source: AIChE Type: Conference PresentationConference Type: AIChE Spring Meeting and Global Congress on Process Safety Presentation Date: April 12, 2016 Duration: 30 minutes Skill Level: Intermediate PDHs: 0.50 Share This Post: Cellulosic ethanol production from lignocellulosic biomass offers a sustainable solution for transition from fossil based fuels to renewable alternatives. However, a few long-standing technical challenges remain to be addressed in the development of an economically viable fermentation process from lignocellulose. Such challenges include the needs to improve yeast tolerance to toxic inhibitory compounds and to achieve high fermentation efficiency with minimum detoxification steps after a pretreatment of the biomass. We developed an in-situ detoxification strategy by exo-protection of an industrial dry yeast (starch-base) with polymeric materials that are compatible with the yeast. The exo-protected yeast cells displayed remarkably boosted vitality with high tolerance to toxic inhibitory compounds such as phenolic and furanic compounds, and with largely improved ethanol productivity from crude lignocellulosic hydrolysates derived from pretreated lignocellulose. The chemical exo-protection makes the industrial S. cerevisiae yeast directly applicable for the production of cellulosic ethanol with substantially improved productivity and yield, without of the need to use genetically modified microorganisms. Copyright © American Institute of Chemical Engineers. All rights reserved.