5th Conference on Constraint-Based Reconstruction and Analysis (COBRA 2018)

October 14-16, 2018

Established and new members of the COBRA community are invited to COBRA 2018 to discuss the latest developments in Constraint-Based Reconstruction and Analysis.

Supported by:

The International Metabolic Engineering Society and the Institute for Systems Biology, chaired by Professor Nathan Price

COBRA 2018 Flyer

COBRA 2018

Metabolic processes and their regulation in response to environmental and genetic perturbations are fundamental to the growth and maintenance of all cells. Linking the genome to its functioning metabolism is therefore of substantial interest in fields ranging from industrial biotechnology to human health. Constraint-based Reconstruction and Analysis (COBRA) has over recent years rapidly expanded and been established as the method of choice for studying cellular metabolism in a global and unbiased fashion. The COBRA 2018 Conference aims to bring together the worldwide COBRA community to discuss latest developments, novel tools and emerging applications in diverse biological research areas, such as metabolic engineering and medicine. The meeting will offer a unique platform for the exchange of ideas and catalyze new, multi-disciplinary collaborations.

Invited Speakers:

Check out the full line up of Speakers featured at COBRA 2018!


  • New Frontiers
  • Methods & Software
  • Application in Metabolic Engineering
  • Applications in Medicine
  • Multi-scale Modeling

Conference Chair:

Organizing Committee:


2018 COBRA Awards

The COBRA Conference Committee is proud to announce the inaugural COBRA Awards. COBRA 2018 will showcase two awards, presented to outstanding and distinguished individuals for their noteworthy scientific work.

Featured Speakers

Evrim Acar

Evrim Acar is a Senior Research Scientist at Simula Metropolitan Center for Digital Engineering. Her research focuses on data mining, in particular, tensor factorizations, data fusion using coupled factorizations of higher-order tensors and matrices, and their applications in diverse disciplines.Read more

Vassily Hatzimanikatis

Dr. Vassily Hatzimanikatis is currently Associate Professor of Chemical Engineering and Bioengineering at Ecole Polytechnique Federale de Lausanne (EPFL), in Lausanne, Switzerland. Dr. Hatzimanikatis is also Editor-in-Chief of Metabolic Engineering Communication, and associate editor of the journals Metabolic Engineering, Biotechnology & Bioengineering and Integrative Biology, and Senior Editor of Biotechnology Journal.Read more

Matthias Heinemann

Matthias Heinemann is full professor for molecular systems biology at the University of Groningen in the Netherlands. In his research, he aims to understand how primary carbon and energy metabolism functions and how it controls other cellular processes.Read more

Nathan E. Lewis

Dr. Lewis is an Assistant Professor of Pediatrics and Bioengineering at the University of California, San Diego. Dr. Lewis' lab focuses heavily on the use of systems biology and genome editing techniques to map out and engineer the cell pathways controlling mammalian cell growth, protein synthesis, and protein glycosylation.Read more

Christian Lieven

Christian Lieven is a Post-Doc at the Novo Nordisk Foundation Center for Biosustainability. Christian is interested in emerging technologies to harness the potential of C1 feedstocks, high-quality software development for the scientific community, and the standardization and maintenance of genome-scale metabolic reconstructions. Recently, he has joined the DD-DeCaF project which is focused on building services for data-driven design of cell factories and communitiesRead more

Costas Maranas

Dr. Costas D. Maranas (b. 1967) is the Donald B. Broughton Professor in the Department of Chemical Engineering at The Pennsylvania State University. The C. Maranas group develops and deploys computational framework informed by systems engineering and mathematical optimization to understand, analyze and redesign metabolism and proteins.Read more

Jens Nielsen

Jens Nielsen has received numerous Danish and international awards including the Villum Kann Rasmussen’s Årslegat, Merck Award for Metabolic Engineering, Amgen Award for Biochemical Engineering, Nature Mentor Award, the Gaden Award, the Norblad-Ekstrand gold medal, the Novozymes Prize, the ENI Award and the Eric and Sheila Samson Prize. He is member of several academies, including the National Academy of Engineering and National Academy of Sciences in USA, the Royal Swedish Academy of Science, the Royal Danish Academy of Science and Letters, the Royal Swedish Academy of Engineering Sciences and the American Academy of Microbiology. He is a founding president of the International Metabolic Engineering Society.Read more

Bernhard Palsson

Bernhard Palsson is the Galletti Professor of Bioengineering, the Principal Investigator of the Systems Biology Research Group in the Department of Bioengineering, and Professor of Pediatrics at the University of California, San Diego. He is also the CEO of the Novo Nordisk Center for Biosustainability in Denmark, working in this capacity since 2011. His research includes the development of methods to analyze metabolic dynamics (flux-balance analysis, and modal analysis), and the formulation of complete models of selected cells (the red blood cell, E. coli, CHO cells, and several human pathogens).Read more

Jennifer Reed

Jennifer Reed is a Professor at the University of Wisconsin-Madison. Her research interests involve building, analyzing, and utilizing metabolic and regulatory models of organisms involved in bioremediation, biofuels, and pharmaceutical applications.Read more

Eytan Ruppin

Eytan Ruppin (MD, PhD) research is focused on developing and harnessing data science approaches for the integration of multi-omics data to better understand the pathogenesis of cancer, its evolution and treatment.Read more

Uwe Sauer

Uwe Sauer is Professor of Systems Biology in the Department of Biology at the ETH Zurich. Research in the Sauer lab takes an interdisciplinary approach that combines quantitative experimentation and modelling to solve fundamental questions of how bacteria and yeasts coordinate their metabolism and how they interact with each other and various hosts.Read more

Ines Thiele

Professor Ines Thiele is the group leader of the Molecular Systems Physiology group at the Luxembourg Centre for Systems Biomedicine and an Associate Professor for Systems Biomedicine at the University of Luxembourg. Her research aims to improve the understanding of how diet influences human health.Read more


Proceedings of the 5th Conference on Constraint-Based Reconstruction and Analysis (COBRA 2018) are now available: