5th Conference on Constraint-Based Reconstruction and Analysis (COBRA 2018)

October 14-16, 2018
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Established and new members of the COBRA community are invited to COBRA 2018 to discuss the latest developments in Constraint-Based Reconstruction and Analysis.

Supported by:

The International Metabolic Engineering Society and the Institute for Systems Biology, chaired by Professor Nathan Price

Register before September 13th, 2018 for Early Bird Pricing

Register Now!

Call for Abstracts is now open until July 13th, 2018

Submit your Abstract Here

COBRA 2018

Metabolic processes and their regulation in response to environmental and genetic perturbations are fundamental to the growth and maintenance of all cells. Linking the genome to its functioning metabolism is therefore of substantial interest in fields ranging from industrial biotechnology to human health. Constraint-based Reconstruction and Analysis (COBRA) has over recent years rapidly expanded and been established as the method of choice for studying cellular metabolism in a global and unbiased fashion. The COBRA 2018 Conference aims to bring together the worldwide COBRA community to discuss latest developments, novel tools and emerging applications in diverse biological research areas, such as metabolic engineering and medicine. The meeting will offer a unique platform for the exchange of ideas and catalyze new, multi-disciplinary collaborations.

Conference Chair:

  • Nathan Price, Institute for Systems Biology

Organizing Committee:

  • Markus Herrgård, Novo Nordisk Foundation Center for Biosustainability
  • Jason Papin, University of Virginia
  • Kiran Patil, European Molecular Biology Laboratory
  • Tomer Shlomi, Technion - Israel Institute of Technology
  • Vangelis Simeonidis, Institute for Systems Biology
  • Ines Thiele, Luxembourg Centre for Systems Biomedicine


  • New Frontiers
  • Methods & Software
  • Application in Metabolic Engineering
  • Applications in Medicine
  • Multi-scale Modeling


  • Evrim Acar, University of Copenhagen
  • Vassily Hatzimanikatis, Ecole Polytechnique Federale de Lausanne
  • Nathan Lewis, University of California San Diego
  • Christian Lieven, Technical University of Denmark
  • Costas Maranas, The Pennsylvania State University
  • Jens Nielsen, Chalmers University of Technology
  • Bernhard Palsson, University of California San Diego
  • Jennifer Reed, University of Wisconsin-Madison
  • Eytan Ruppin, University of Maryland Institute for Advanced Computer Studies
  • Uwe Sauer, Eidgenössische Technische Hochschule Zürich
  • Ines Thiele, Luxembourg Centre for Systems Biomedicine

Featured Speakers

Evrim Acar

Evrim Acar is a Senior Research Scientist at Simula Research Laboratory. Her research interests are data mining and mathematical modeling; in particular, tensor decompositions, data fusion using coupled factorizations of higher-order tensors and matrices, and their applications in social network analysis, computational neuroscience, metabolomics and chemometrics.Read more

Vassily Hatzimanikatis

Dr. Vassily Hatzimanikatis is currently Associate Professor of Chemical Engineering and Bioengineering at Ecole Polytechnique Federale de Lausanne (EPFL), in Lausanne, Switzerland. Dr. Hatzimanikatis is also Editor-in-Chief of Metabolic Engineering Communication, and associate editor of the journals Metabolic Engineering, Biotechnology & Bioengineering and Integrative Biology, and Senior Editor of Biotechnology Journal.Read more

Nathan E. Lewis

Dr. Lewis is an Assistant Professor of Pediatrics and Bioengineering at the University of California, San Diego. Dr. Lewis' lab focuses heavily on the use of systems biology and genome editing techniques to map out and engineer the cell pathways controlling mammalian cell growth, protein synthesis, and protein glycosylation.Read more

Christian Lieven

Christian Lieven is currently finishing his PhD in Bioengineering. During his PhD in the Design group of the iLoop Core, a translational research unit focused on microbial cell factory engineering at the Center for Biosustainability, Christian has been working on the EFPro2 project: in collaboration with other researchers from the University of Southern Denmark, Aarhus University, Vestjyllands Andel and Unibio A/S he reconstructed a genome-scale metabolic model for the methanotroph Methylococcus capsulatus. Christian is interested in emerging technologies to harness the potential of C1 feedstocks, software development, and the standardization and maintenance of genome-scale metabolic reconstructions.Read more

Costas D. Maranas

Dr. Costas D. Maranas (b. 1967) is the Donald B. Broughton Professor in the Department of Chemical Engineering at The Pennsylvania State University. The C. Maranas group develops and deploys computational framework informed by systems engineering and mathematical optimization to understand, analyze and redesign metabolism and proteins.Read more

Jens Nielsen

In 2008, Jens Nielsen was recruited as Professor and Director to Chalmers University of Technology, Sweden, where he is currently directing a research group of more than 50 people. At Chalmers he established the Area of Advance Life Science Engineering, a cross departmental strategic research initiative and was founding Head of the Department of Biology and Biological Engineering, which now encompass more than 170 people.Read more

Bernhard Palsson

Bernhard Palsson is the Galletti Professor of Bioengineering, the Principal Investigator of the Systems Biology Research Group in the Department of Bioengineering, and Professor of Pediatrics at the University of California, San Diego. He is also the CEO of the Novo Nordisk Center for Biosustainability in Denmark, working in this capacity since 2011. His research includes the development of methods to analyze metabolic dynamics (flux-balance analysis, and modal analysis), and the formulation of complete models of selected cells (the red blood cell, E. coli, CHO cells, and several human pathogens).Read more

Jennifer Reed

Jennifer Reed is the Harvey D. Spangler Faculty Scholar in the College of Engineering and Associate Professor at the University of Wisconsin-Madison. Her research interests involve building, analyzing, and utilizing metabolic and regulatory models of organisms involved in bioremediation, biofuels, and pharmaceutical applications. Read more

Eytan Ruppin

Eytan Ruppin (MD, PhD) research is focused on developing and harnessing data science approaches for the integration of multi-omics data to better understand the pathogenesis of cancer, its evolution and treatment.Read more

Uwe Sauer

Uwe Sauer is Professor of Systems Biology in the Department of Biology at the ETH Zurich. Research in the Sauer lab takes an interdisciplinary approach that combines quantitative experimentation and modelling to solve fundamental questions of how bacteria and yeasts coordinate their metabolism and how they interact with each other and various hosts.Read more

Ines Thiele

Professor Ines Thiele is the group leader of the Molecular Systems Physiology group at the Luxembourg Centre for Systems Biomedicine and an Associate Professor for Systems Biomedicine at the University of Luxembourg. Her research aims to improve the understanding of how diet influences human health.Read more