Uwe Sauer is Professor of Systems Biology in the Department of Biology at the ETH Zurich. He earned his MS and PhD in microbiology from the University of Göttingen. During his postdoc work on metabolic engineering in the chemical engineering lab of Jay Bailey in Zurich, he became interested in computational modelling of cellular behavior and quantitative analysis of intracellular fluxes in particular. In the late nineties, his research began to focus on quantitative understanding of interactions and regulation within complex microbial metabolic networks by using and developing cutting-edge experimental and computational methods.
For this purpose, research in the Sauer lab takes an interdisciplinary approach that combines quantitative experimentation and modelling to solve fundamental questions of how bacteria and yeasts coordinate their metabolism and how they interact with each other and various hosts. In particular, his lab has pioneered quantitative mass spectrometry-based methods for 13C-flux analysis and high-throughput metabolomics, enabling rapid hypothesis generation on the molecular and functional operation of complex metabolic networks.
Uwe has over 200 publications in peer-reviewed journals, and is a member of various international editorial boards, scientific steering and advisory committees of organizations and companies in systems biology and biotechnology.