Ines Thiele

Ines Thiele

Associate Professor
Luxembourg Centre for Systems Biomedicine

Ines Thiele is an associate professor in systems biomedicine and principal investigator in the Molecular Systems Physiology group (Thiele Lab). Works at the Luxembourg Centre for Systems Biomedicine and has contributed to the research of functional metabolic modeling of the human gut Microbiota, gene variation in human metabolism and modeling metabolism of the human gut microbiome.


The Molecular Systems Physiology group, headed by Dr. Ines Thiele, aims to improve our understanding of how diet influences human health.

We use a computational modeling approach, termed constraint-based modeling, which has gained increasing importance in systems biology. In this approach, comprehensive computational models are assembled in a bottom-up manner from literature and genomic information. These models describe in a stoichiometric accurate format biochemical transformations occurring in a target organism. Once assembled, various omics data sets can be integrated and analyzed with these models, expanding currently available analysis tools and thus providing mechanistically based insight into complex multi-dimensional data sets. Moreover, these models can be used to predict the impact of genetic alterations (e.g., enzyme deficiencies) and of changed environment conditions (e.g., changes in diet composition) on the metabolic state of the target organism.

The molecular systems physiology group builds comprehensive models of human cells and human-associated microbes. We then employ these models together with experimental data to investigate how nutrition and genetic predisposition can affect one’s health. In particular, we are interested in applying our computational modeling approach for better understanding inherited and neurodegenerative diseases.

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