Society for Biological Engineering (SBE) SBE is a global technological community that promotes the integration of engineering with biology and realize its benefits through bioprocessing, biomedical, and biomolecular applications. SBE provides opportunities for interaction of engineers and scientists, develops products and services bring value to the broad biological engineering community, and infuses awareness of biological engineering among all functions and activities of AIChE.
Food, Pharmaceutical & Bioengineering Division (FP & BE) The FP&BE division coordinates AIChE's activities in the fields of food, pharmaceuticals, and bioengineering.
Forest Bioproducts Division (FBP) The Forest Bioproducts Division promotes knowledge sharing and networking on topics dealing with products obtained from forest resources and other lignocellulosic materials.
Quantitative Modeling and Analysis of TGF-ß-Induced Erk/MAPK and Smad Signaling Conference PresentationAIChE Annual MeetingNovember 9, 2010Transforming growth factor ß (TGF-ß), which plays a pivotal role in regulating a wide array of cellular and physiologic processes in both normal and...
Risk Based Roadmap for the Approval of Biosimilar Biologics Conference PresentationAIChE Annual MeetingNovember 9, 2010The development of biologics has grown significantly in recent years, due in part to the profitability for innovator companies, which currently enjoy...
In Silico Modeling of the Immune Response Network: Influenza Immune-Escape Strategies and Implications in Influenza Drug Research Conference PresentationAIChE Annual MeetingNovember 9, 2010Recent evidence suggests that an overly ambitious immune response may be the primary factor that determines influenza severity [1], yet the...
Optimal Material Selection for Oral Dosage Development and Manufacture Using Optimization Techniques and Multivariate Latent Variable Models Conference PresentationAIChE Annual MeetingNovember 9, 2010Multivariate latent variable models (such as Principal Components Analysis –PCA, and Projection to Latent Structures –PLS) have been reported in...
Sustainably Produced Sugars From Biomass: The Key to Commercialization Conference PresentationAIChE Annual MeetingNovember 9, 2010Novozymes has launched the first commercially viable product for conversion of complex biomass to fermentable sugars. Continued enzyme improvement...
Real-Time Monitoring of Continuous Processes with Spectroscopic PAT-Tools Conference PresentationAIChE Annual MeetingNovember 9, 2010The aim of Process Analytical Technology (PAT) is to gain deeper insight in pharmaceutical manufacturing processes, replacing empirical approaches by...
On-Line Monitoring of Roller Compaction Ribbon Density Using NIR Spectroscopy Conference PresentationAIChE Annual MeetingNovember 9, 2010Solid dosage forms, such as tablets and capsules, have been predominately manufactured through batch processes in pharmaceutical industry for years...
A High Throughput, Parallel, Microscale, Fully Automated Approach to Biologics Formulation Development and Stress Test Studies Conference PresentationAIChE Annual MeetingNovember 9, 2010Developing robust formulations for biological materials (proteins, antibodies, vaccines, etc.) requires the screening and analysis of a comprehensive...
The Implications of Bioenergy Derived From Forests for Net Greenhouse Gas Emissions Conference PresentationAIChE Annual MeetingNovember 9, 2010Greenhouse gas (GHG) accounting systems consider bioenergy from forests as carbon neutral because, under international greenhouse gas accounting...
Metabolic Reconstruction and Analysis of Methane Producing Methanosarcina Barkeri Conference PresentationAIChE Annual MeetingNovember 9, 2010Methane is a clean-burning renewable resource that is often overlooked as a potential bioenergy source. Methane already has a well established...
Raman Spectroscopy Combined with Small and Wide Angle X-Ray Scattering as a Non Destructive Quality Control Tool for Powder Compression Analytics in Pharmaceutical Applications Conference PresentationAIChE Annual MeetingNovember 9, 2010This study evaluates the feasibility of a combined use of small-wide angle X-ray scattering (SWAXS) and Raman spectroscopy as a non-invasive process...
Stochastic Simulations of the Tetracycline Operon Conference PresentationAIChE Annual MeetingNovember 9, 2010The tetracycline (tet) operon is a robust self-regulated system. It is found naturally in bacteria where it confers resistance to antibiotic...
Probabilistic Integrative Modeling of Genome-Scale Metabolic and Regulatory Networks in Escherichia Coli and Mycobacterium Tuberculosis Conference PresentationAIChE Annual MeetingNovember 9, 2010Systems biology seeks to understand the cell by studying interactions between its various components and the properties that emerge from these...
Optimizing and Controlling High Value Processes Using the Principles of Quality-by-Design (QbD) Advanced Tools Such as Real-Time in-Situ Particle Characterization, in-Situ Mid-Infrared Spectrometry, and Reaction Calorimetry Conference PresentationAIChE Annual MeetingNovember 9, 2010Quality by Design (QbD) is a concept applied to gain true process understanding utilizing tools such as Design of Experiment (DoE), Risk Management,...
Integration of Signaling Networks with Differential Gene Regulation Data Using a Probabilistic Pathway Impact Analysis Approach Conference PresentationAIChE Annual MeetingNovember 9, 2010The objective of the present study is to integrate the information on intracellular signaling network structures with large-scale gene expression...
Modeling and Analysis of the Retinoic Acid Induced Proliferation and Differentiation Program of HL-60 Conference PresentationAIChE Annual MeetingNovember 9, 2010Understanding the molecular basis of differentiation programs is one of the grand unmet challenges facing modern cell-biology. In this study, we...
Gene Regulation by MAPK Substrate Competition Conference PresentationAIChE Annual MeetingNovember 9, 2010Introduction Traditional view of pattern formation in the early Drosophila embryo is essentially one-dimensional: The anterior, posterior, and...
On-Line Blend Monitoring of Pharmaceutical Materials Using Multiple NIR Sensors Conference PresentationAIChE Annual MeetingNovember 9, 2010In recent years, powder blend monitoring and control systems using process analytical technologies (PAT) have become increasingly popular in the...
Desensitizing near-Infrared Calibration Models for Physical Interferences in Tablets During Formulation/Process Development Conference PresentationAIChE Annual MeetingNovember 9, 2010During formulation/process developments, experimental designs are often used to minimize the number of experiments and maximize the necessary...
Cell Population Heterogeneity and Mass Transport Dynamics Modulate Tissue Regeneration Processes Conference PresentationAIChE Annual MeetingNovember 9, 2010A better understanding of the complex interplay between cell population dynamics and mass transport is necessary for overcoming the barriers that...
Automated Metabolic Network Reconstruction: Method, Application and Web Tool Conference PresentationAIChE Annual MeetingNovember 8, 2010Genome-wide metabolic network reconstruction has proved to be a powerful tool for system-level study of whole-cell metabolisms. A great amount of...
Recent Research Development In Biomass Conversion to Advanced Bio-Fuels Conference PresentationAIChE Annual MeetingNovember 8, 2010The United States is abundant in biomass resources. The Pacific Northwest National Laboratory (PNNL) have been conducting research on conversion of...
A System Approach to Astrocytoma Progression Conference PresentationAIChE Annual MeetingNovember 8, 2010Astrocytomas are brain cancers that account for 75% of neuroepithelial tumors. Accurate diagnosis is required for adequate treatment and assessing...
Optimization-Based Design Space Characterization Using First-Principles Models Conference PresentationAIChE Annual MeetingNovember 8, 2010Placeholder for Pantelides talk
Using Inducible Gene Expression to Characterize Oncogene Cooperation in a Murine Pre-B Cell Line Conference PresentationAIChE Annual MeetingNovember 8, 2010Cancer is caused by multiple gene mutations that each contribute to the transformation of normal cells. There is more to be learned, however, about...
Experimental and Mathematical Approaches to Multi-Scale Analysis of Tumor Necrosis Factor-Regulated Immune Response to Tuberculosis Conference PresentationAIChE Annual MeetingNovember 8, 2010Tuberculosis (TB) is a common and deadly infectious disease caused by a highly successful bacterium, Mycobacterium tuberculosis (Mtb). Multiple host...
Artificial Photosynthesis: The Future of Renewable Fuels and Chemicals Conference PresentationAIChE Annual MeetingNovember 8, 2010This presentation will provide an overview and research vision of catalytic and reaction engineering technologies for conversion of CO2 into re-...
Multi-Scale Agent-Based Modeling of Human Endotoxemia Conference PresentationAIChE Annual MeetingNovember 8, 2010The systemic inflammatory response syndrome (SIRS) often accompanies critical illness but is evoked by many stimuli e.g. infection, trauma, invasive...
Identification of Cell-Type Specific Transcripts for Informative Diagnostics Conference PresentationAIChE Annual MeetingNovember 8, 2010The identification of cell-type specific or brain-region specific transcripts adds specificity for the diagnosis of a wide variety of brain disorders...
Multiscale Modeling and Analysis of TRPV1 Regulation in Sensory Neurons Conference PresentationAIChE Annual MeetingNovember 8, 2010TRPV1 (transient receptor potential vanilloid subtype 1) receptors play a central role in nociception and inflammatory pain. Interestingly, both...
Artificial Photosynthesis: Conversion of CO2 at Low Temperature and Potential Using Ionic Liquids Conference PresentationAIChE Annual MeetingNovember 8, 2010Alternative energy and climate change are among the largest concerns facing scientists and engineers at the start of the twenty-first century. The...
Design Space and QbD: It's All about the (Stochastic) Distributions Conference PresentationAIChE Annual MeetingNovember 8, 2010Added by Shekhar Viswanath on behalf on John Peterson
Quality by Design and Multivariate Process Representations Conference PresentationAIChE Annual MeetingNovember 8, 2010Bioprocess design, development and manufacturing involve different goals and use different tools. At the design stage a cell-centric approach...
Exploring Bistable Molecular Switches and Their Functional Roles Using a Meta-Analysis That Integrates Expression Data with Regulatory Networks Conference PresentationAIChE Annual MeetingNovember 8, 2010An important topic in systems biology is to understand the dynamic properties of the biological networks. Previous studies have provided important...
Microreactor for Industrial Application: Technical and Economical Benefits Conference PresentationAIChE Annual MeetingNovember 8, 2010A glass based high throughput microreactor technology is presented illustrating the basic design window, technical data and configuration. An...
Omics Analysis of Agrobacterium Sp. Uncovers Regulatory Factors for Polysaccharide Biosynthesis Conference PresentationAIChE Annual MeetingNovember 8, 2010Microbial polysaccharides are primary cellular components and integral to many cellular functions including cell adhesion, biofilm formation,...
Genomic Approaches to Evolutionary History of Primate Cytochromes c Conference PresentationAIChE Annual MeetingNovember 8, 2010Cytochrome c (cyt c) is a highly conserved protein among eukaryotes, mainly owing to its pivotal role in two crucial cellular processes: apoptosis...
Comprehensive Analysis of Liver Transcriptome Reveals Distinct Disease Signatures Conference PresentationAIChE Annual MeetingNovember 8, 2010Major liver diseases such as hepatocellular carcinoma, cirrhosis, and hepatitis affect huge numbers of people. For example, each year, death from...
Accelerated Development and Improved Process Operations Using Advanced Multivariate Latent Variable Modeling Conference PresentationAIChE Annual MeetingNovember 8, 2010This talk will focus on the use of advanced multivariate latent variable models to aid the accelerated development of the product and the process, as...
Chronic Alcohol Effects On the System-Wide Transcriptional Regulatory Network Modules and Dynamics During Rat Liver Regeneration Conference PresentationAIChE Annual MeetingNovember 8, 2010Liver regeneration is a complex, yet remarkably coordinated, process characterized by system-wide gene expression changes underlying the response of...
A Comprehensive Profiling of Genome-Wide Transcriptional Programs of Primary Hepatocytes in Vitro Cultures Conference PresentationAIChE Annual MeetingNovember 8, 2010The liver is one of most important organs in our bodies and performs many essential functions including metabolism, synthesis, secretion,...
Gene Expression Profiling of Short- and Long-Term Changes in Rat Liver Following Burn Injury and CLP Treatment Conference PresentationAIChE Annual MeetingNovember 8, 2010An important player in systemic hypermetabolism is the liver, which generally controls circulating levels of metabolites. It is well known that the...
Design and Construction of a Protein Degradation Switch Conference PresentationAIChE Annual MeetingNovember 7, 2010Targeted protein degradation in eukaryotic cells requires recruitment of the target protein to proteasome which is usually triggered by...
QbD for Generic Drugs: Modified Release Drug Products Conference PresentationAIChE Annual MeetingNovember 7, 2010The Office of Generic Drugs ensures the therapeutic equivalence and quality of generic drug product pharmaceuticals. This is based principally upon a...
Modeling Eukaryotic Unfolded Protein Response and Its Role in Cellular Stress Conference PresentationAIChE Annual MeetingNovember 7, 2010Malfunctions in the folding state of critical proteins have been linked with cancer, diabetes and other diseases. Proteins requiring complex post-...
QbD for Generic Drugs: A Case Study for Immediate-Release Products Conference PresentationAIChE Annual MeetingNovember 7, 2010Quality by design (QbD) is a systematic approach for product and process design and development to ensure predefined product quality. Although the...
Using Synthetic Biology to Engineer Syntrophic Microbial Communities for Bioprocess Applications Conference PresentationAIChE Annual MeetingNovember 7, 2010A combination of synthetic biology and in silico network analysis was used to construct artificial microbial consortia comprised of engineered...
Model-Driven Minimization of the B. Subtilis Genome Conference PresentationAIChE Annual MeetingNovember 7, 2010Bacillus subtilis is a gram positive, sporulating bacteria often utilized in industry as a producer of high quality enzymes and proteins [1]. The...
Novel, Synthetic, Tetracycline-Inducible Transcription Regulators for E. Coli Conference PresentationAIChE Annual MeetingNovember 7, 2010We are designing, constructing and characterizing novel synthetic gene regulators. These regulators range from individual inducible fusion protein...
A Quality by Design Approach to Scale-up of the Melt-Spray-Congeal Multiparticulate Process Conference PresentationAIChE Annual MeetingNovember 7, 2010The melt-spray-congeal (MSC) process is a rotary atomization technique for the production of a multiparticulate pharmaceutical dosage form. The final...
A Microrna Based Synthetic Network as Stable Expression Unit in Mammalian Cells Conference PresentationAIChE Annual MeetingNovember 7, 2010The utility and scalability of complex synthetic gene networks is hampered by fluctuations in stoichiometry between different gene products in...
QbD for Generic Drugs: Oral Suspensions Conference PresentationAIChE Annual MeetingNovember 7, 2010The presentation will be focus on the approach for systematic development of oral suspensions. Suspension is a complex dosage form in which coarse...
A Spectrophotometric Method for Quantitative Determination of Xylose In Fermentation Medium Conference PresentationAIChE Annual MeetingNovember 7, 2010The characterization of released sugars during fermentation is very important. Difficulty arises in the availability of a rapid, inexpensive and...
Characterization of Tablet Attritional Forces in a Friability Tester and Film Coating Pan Using DEM Conference PresentationAIChE Annual MeetingNovember 7, 2010The objective of this work was to better understand the forces generated on tablets in the friability tester and pan coater using discrete element...
Toward a More Reliable USP Dissolution Testing Apparatus II Conference PresentationAIChE Annual MeetingNovember 7, 2010In the pharmaceutical industry, dissolution testing is a critical step in quality control and a standard method for assessing batch-to-batch...
QbD in Generic Drug Development: PAT Application Conference PresentationAIChE Annual MeetingNovember 7, 2010A generic drug product is pharmaceutically and therapeutically equivalent to a Reference Listed Drug (RLD) product. It meets the same requirements...
Directed Evolution of Quorum-Sensing Dependent Transcriptional Repressors for Programmed Intercellular Communication Conference PresentationAIChE Annual MeetingNovember 7, 2010One of the key challenges in the field of synthetic biology is to engineer not only single cells but also communities of cells that exhibit...
Quality by Design for Generic Drugs: Overview Conference PresentationAIChE Annual MeetingNovember 7, 2010Quality by design is an essential part of the modern approach to pharmaceutical quality. But there is uncertainty in the generic drug industry about...
Quality by Design in Pharmaceutical Development Conference PresentationAIChE Annual MeetingNovember 7, 2010More than 70% of the prescriptions in the US are now filled with generic products, and therefore, the industry has the responsibility to continue to...
Using Qualitative Models to Capture and Demonstrate Process Understanding Conference PresentationAIChE Annual MeetingNovember 7, 2010This presentation will cover how qualitative models can be used to capture and demonstrate process understanding and improve communication between...
Non-Thermal Plasma Reforming of Refractory Tars and Oils Generated by Biomass Gasification Conference PresentationAIChE Spring Meeting and Global Congress on Process SafetyMarch 22, 2010One of the barriers to wider use of many kinds of biomass is the fact that they generate refractory tars and oils when gasified. These compounds...
The Catalytic Conversion of Bioproducts to Fuels Conference PresentationAIChE Annual MeetingNovember 17, 2008
Success and Prospects in Bioengineering Conference PresentationAIChE Annual MeetingNovember 16, 2008Chemical engineers have always played an important role in the development of biotechnology. From the first efforts to effectively produce penicillin...
Frances Arnold: Doing a World of Good In this episode of the Foundation’s Doing a World of Good podcast, you'll meet Frances Arnold who talks about her work in directed evolution. Listen on the Giving site or subscribe in iTunes.
Technique Identifies Influenza Mutations' Pandemic Potential July 7, 2017A new technique labels gene segments to help understand how the virus enters a cell and establishes co-infections.
Genetic Variation Identifies High-Risk Flu Patients July 18, 2017Researchers have identified an inherited genetic variation that they believe helps identify those at the highest risk for potentially fatal influenza infections. Among the...
Micro Silk Cocoons Could Be Used in Food and Medicine July 19, 2017Microscopic versions of silkworm cocoons that could be used to protect sensitive molecular materials.
BioTM Articles Topping Altmetrics Charts June 27, 2017In its first year, BioTM is already topping the charts, with top ratings for viewing, sharing, and discussion of articles.
Self-Disposing Materials Created in Search for Recycling Alternative July 21, 2017In an attempt to find alternatives to conventional recycling, researchers at the Technical University of Munich took inspiration from nature to create a self-disposing...
Bioengineers, Doctors Unveil Sepsis Test Requiring One Drop of Blood July 5, 2017New lab-on-a-chip technology looks at immune response for early sepsis detection.
2018 Spring Meeting and 14th Global Congress on Process Safety April 22-26, 2018 Orlando World Center MarriottThe AIChE Spring Meeting is the year’s key technical conference for practicing chemical engineers. A wide range of subjects relevant to the current needs of industry is covered.
ISPE Conference and Exhibition 2017 August 23-26, 2017Suntec Singapore Convention & Exhibition CentreOrganized by the Singapore affiliate of the International Society for Pharmaceutical Engineering (ISPE), this annual meeting is open to all pharma and bio manufacturing Professionals. It is the must-attend industry event which highlights best practices, technology and services from manufacturing...
New H1N1 Flu Virus Sensor Is Rapid and Highly Sensitive June 1, 2017A new biosensor is capable of rapid detection of the H1N1 flu virus, a strain which poses a strong treat for pandemic outbreak. The new sensor, developed by researchers at Tokyo...
Profile: Developing Novel Solutions to Improve Patient Care June2017ProfileLonnie Shea, a professor and chair in the Dept. of Biomedical Engineering at the Univ. of Michigan, is an internationally recognized researcher whose work spans the fields of regenerative medicine, biomaterials, and gene and drug delivery. His research seeks to advance technologies and solutions at the interface of engineering and medicine.
Technical Entity Trends: A World Transitioning to Translational Medicine June 2, 2017The failure rate for new drugs and therapies under development exceeds 95%. For the other 5%, it takes at least 14 years and more than $1 billion to develop a successful candidate...
New Biodiesel Fully Compatible with Conventional Engines June 20, 2017Until now, biodiesel could not be used undiluted in a conventional diesel engine since its boiling point is higher than that of petroleum diesel.
Enzyme Destroys Biofilm of Multiple Organisms June 26, 2017Instead of targeting individual microbes, researchers went after the biofilm that protects them and found great success.
Giant Molecular Cages Maximize Efficiency of Converting Molecules in Chemical Reactions June 30, 2017The molecular cages show potential for use in energy conversion, drug delivery, and as sensors.
Catalyzing Commercialization: Sustainable Production of Bricks Promises to Curb Global Emissions June2017Catalyzing CommercializationbioMASON, a start-up located in Research Triangle Park, NC, has developed a process for “growing” bricks at room temperature rather than firing them in kilns. The process employs bacteria to grow the building materials without emitting greenhouse gases, and without depleting nonrenewable resources.