AIChE Journal Highlight: Advancing Quality by Design in Pharmaceuticals May2018Journal HighlightAlthough pharmaceutical manufacturing has a rich history of delivering lifesaving drugs and therapies to patients, quality control concerns within manufacturing facilities as well as patient safety incidents prompted the creation of regulatory...
Expo Preview: INTERPHEX 2018 March2018New ProductsINTERPHEX is an annual event dedicated to showcasing pharmaceutical and biopharmaceutical innovation, technology, and knowledge. It brings together over 11,000 global pharmaceutical and biotechnology professionals for exhibitions, education,...
Process Modeling and Simulation for Continuous Pharmaceutical Manufacturing of Diphenhydramine Conference PresentationAIChE Annual MeetingNovember 10, 2015Continuous Pharmaceutical Manufacturing (CPM) has been recognized as an increasingly promising multidisciplinary research domain, addressing the...
Implementation of Advanced Multilayer Plant-Wide Control Architecture into a Direct Compaction Continuous Pharmaceutical Manufacturing Process Conference PresentationAIChE Annual MeetingNovember 9, 2015Continuous pharmaceutical manufacturing provides an appropriate platform where feed-forward and feedback control strategies, including necessary...
Technoeconomic Optimization for Green Continuous Pharmaceutical Manufacturing of Analgesics Conference PresentationAIChE Annual MeetingNovember 9, 2015Continuous Pharmaceutical Manufacturing (CPM) has recently emerged as a promising alternative to the currently dominant batch production methods...
Plant-Wide Hybrid MPC-PID Control of a Continuous Direct Compaction Tablet Manufacturing Pilot-Plant for QbD Based Pharmaceutical Manufacturing Conference PresentationAIChE Annual MeetingNovember 20, 2014It is highly desired to implement a closed-loop feedback control system into a pharmaceutical manufacturing plant to enable the transition toward a...
Modeling of Residence Time Distribution in Continuous Solid Oral Dose Pharmaceutical Manufacturing Processes Conference PresentationAIChE Annual MeetingNovember 20, 2014Modeling of Residence Time Distribution in Continuous Solid Oral Dose Pharmaceutical Manufacturing Processes M. Sebastian Escotet-Espinoza, Amanda...
Process Modeling, Simulation and Optimization for Continuous Pharmaceutical Manufacturing (CPM) of Ibuprofen Conference PresentationAIChE Annual MeetingNovember 18, 2014Pharmaceutical corporations face rapidly rising R&D as well as production costs. Batch production processes are dominant in the pharmaceutical...
Optimal Design of Antibody Downstream Process of Biopharmaceutical Manufacturing Conference PresentationAIChE Annual MeetingNovember 6, 2013With the increasing market potential of therapeutic monoclonal antibodies (mAbs) , it has become critical to rapidly identify the most cost-effective...
Exceptional Event Managemnt Applied to Continuous Pharmaceutical Manufacturing Conference PresentationAIChE Annual MeetingOctober 29, 2012One of the important challenges in effective real time process management is the implementation of intelligent systems that can assist human...
New Challenges and Opportunities for Pharmaceutical Manufacturing Science Conference PresentationAIChE Annual MeetingOctober 29, 2012New Challenges and Opportunities for Pharmaceutical Manufacturing Science Vincent L Vilker and Mansoor A Khan, CDER/FDA The increasing sophistication...
Looking to the Future in Continuous Pharmaceutical Manufacturing Conference PresentationAIChE Annual MeetingOctober 29, 2012This presentation describes the motivations, challenges, and opportunities in continuous pharmaceutical manufacturing. Some of the motivations are...
QUALITY by Design (QBD), Biopharmaceutical Manufacture Conference PresentationAIChE Annual MeetingOctober 17, 2011In the biopharmaceutical industry, consistently manufacturing a safe and high quality protein drug substance can be challenging. Recently, a...
Real-Time Process Management and Knowledge Management for Continuous Pharmaceutical Manufacturing Conference PresentationAIChE Annual MeetingOctober 16, 2011The manufacture of pharmaceutical drug products has benefited significantly from a QbD approach, including the enabling of continuous production over...
Real-Time Monitoring of Pharmaceutical Manufacturing Processes with a Multiplexed Optical Fiber Probe NIR-Setup Conference PresentationAIChE Annual MeetingNovember 9, 2010Diffuse reflectance near-infrared (NIR) spectroscopy is a non-invasive and widely used technology with the potential for a wide range of applications...
Comprehensive Quality by Design for Pharmaceutical Product Development and Manufacture October, 2017This book provides a broad view of Quality by Design (QbD) and shows how QbD concepts and analysis facilitate the development and manufacture of high quality pharmaceutical products. QbD is seen as a framework for building process understanding, for implementing robust and effective manufacturing...
AIChE Journal Highlight: Creating Computational Models for Biopharmaceutical Production February2017Journal HighlightGenerating revenue of $163 billion, the biopharmaceutical industry accounts for 20% of the global pharmaceutical market. And, annual revenue growth for biopharmaceuticals is 8%, double that of conventional pharmaceutical products. Within a...
INTERPHEX Expo Preview February2017New ProductsINTERPHEX is an annual event dedicated to showcasing pharmaceutical and biopharmaceutical innovation, technology, and knowledge. It brings together over 12,000 global pharmaceutical and biotechnology professionals for exhibitions, education,...
AIChE Journal Highlight: Moving Toward Continuous Pharmaceutical Manufacturing June2016Journal HighlightOver the past decade, the pharmaceutical industry has experienced several important changes in its business environment that are driving efforts to reduce overall cost while improving process understanding and product quality without the traditional...