AIChE Journal Highlight: Probabilistic Modeling to Drive Pharmaceutical Development November2019Journal HighlightOver the past 15 years, the pharmaceutical industry has undergone much transformation. Drug targets ( i.e., proteins associated with a particular disease process) have grown more challenging and the molecules required to hit those targets have...
Technical Entity Trends: Artificial Intelligence Marks A New Drug Lifecycle June2019Technical Entity TrendsExpedito SegoviaA wave of change is spreading across many industries due to technological advances enabled by artificial intelligence (AI) and automation. The pharmaceutical industry is no exception and is harnessing AI tools for new drug discovery and development...
Featured Engage Discussions: April 2019 April 29, 2019Wondering what others are talking about? Check out the latest technical and career discussions on AIChE Engage.
Meet Process Engineer Jacob Albrecht November 21, 2018Jacob Albrecht discusses the challenging but enjoyable road to manufacturing new medicines, and the creative aspects of process engineering.
Meet Process Engineer Yangmu Liu June 28, 2018Process engineers are bringing improved manufacturing to the pharmaceuticals industry. Read one process engineer's take on her work in the industry.
Is Synthetic Biology Having a Moment? February 15, 2019Suddenly, synthetic biology is being discussed a lot beyond the walls of academia and the pages of scientific journals. Today, it abounds in the mainstream press.
CEP: News Update February2019News UpdateA Hub for Appalachia’s Emerging Petrochemical Industry A recent U.S. Dept. of Energy (DOE) report highlights the potential benefits of Appalachia Development Group’s (ADG) proposed infrastructure project, the over $3 billion Appalachian Storage and...
CAR T-Cell Therapy Individualizes Cancer Treatment December 27, 2018The market for chimeric antigen receptor (CAR) T-cell therapy is projected to be valued at almost $300 million by the end of 2018, and this number is expected to grow annually by 32% for the next decade.
Ryan C. Snyder, Bucknell University: The Future of Chemical Engineering September 8, 2018Hear Ryan's perspective on what advances he thinks chemical engineering has ahead of it.
Robert Steininger, Surface Oncology Inc.: The Future of Chemical Engineering August 28, 2018A look at the future of chemical engineering from the perspective of pharmaceutical manufacturing.
Technical Entity Trends: Engineer Your Gut August 31, 2018Humans have roughly 40 trillion bacterial cells in their bodies; up to 1,000 species of bacteria live in the human gut alone.
CEP: News Update August2018News UpdateNew CRISPR Findings Raise Concerns Before Technology’s Clinical Debut A pair of studies that investigated the effect of CRISPR-Cas 9 on a key protein that regulates cell growth and protects against cancer has sent shockwaves through the growing...
Small Proteins Seen in Near-Atomic Detail April 17, 2018UCLA biochemists have harnessed cryo-electron microscopy to see near-atomic detail in much smaller proteins than ever before.
Chemical Engineers Completely Simulate Penicillin Production April 11, 2018Microorganisms have long been used to help humans carry out various processes such as brewing and the production of antibiotics, but these processes remain very complex, with bioreactors seen as “b
Broad-Spectrum Antiviral Shown to Inhibit Coronaviruses March 7, 2018A new experimental broad-spectrum antiviral drug could be used to combat the type of virus that causes the common cold and pneumonia, as well as more lethal viruses such as SARS and MERS.
Biological Engineers Have Challenge in Antibiotic Resistance February 28, 2018A new report released by the European Centre for Disease Prevention and control (ECDC) emphasizes that antimicrobial resistance remains one of the greatest public health threats today.
Nanoparticle Designed to Destroy Harmful Viruses January 4, 2018An international team of researchers has created new antiviral nanoparticles that show potential for outperforming current antiviral drugs.
New Structural Knowledge of Key Protein May Improve Drug Design January 3, 2018New imagine of a key protein's signaling mechanism provides insights for better pharmaceuticals.
Brain on Chip Aims to Reduce Human and Animal Testing December 26, 2017The device aims to test and predict the effects of biological and chemical agents, diseases, or drugs on the brain without the need for human or animal subjects.
IQ Consortium Enabling Technologies for Pharma Conference PresentationAIChE Annual MeetingNovember 9, 2015The International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) is a technically-focused organization of pharmaceutical...
Practical Application of Q8 and Q9 Principles in Pharmaceutical Development Conference PresentationAIChE Annual MeetingNovember 10, 2010The presentation “Practical application of Q8 and Q9 principles in pharmaceutical development” gives an overview of the current practice in...
Quality by Design in Pharmaceutical Development Conference PresentationAIChE Annual MeetingNovember 7, 2010More than 70% of the prescriptions in the US are now filled with generic products, and therefore, the industry has the responsibility to continue to...
Comprehensive Quality by Design for Pharmaceutical Product Development and Manufacture October, 2017This book provides a broad view of Quality by Design (QbD) and shows how QbD concepts and analysis facilitate the development and manufacture of high quality pharmaceutical products. QbD is seen as a framework for building process understanding, for implementing robust and effective manufacturing...
Engineering Cancer-Fighting T Cells October2017SBE Special SectionEugenia Zah, Yvonne Y. ChenAdoptive T-cell therapy is a personalized cancer treatment that has the potential to cure previously untreatable malignancies. Researchers are applying techniques in biomolecular engineering and synthetic biology to the development of next-generation therapeutic T cells with improved safety and efficacy against a variety of cancers.
A Materials Approach to Vaccines as Therapies October2017SBE Special SectionNeil Dold, Christopher M. JewellThe widespread adoption of vaccines over the last two centuries has transformed medicine by preventing infectious disease. In the future, so-called therapeutic vaccines could be used as effective treatments for cancer and autoimmune disorders — ushering in a new era of medicine.
Technique Identifies Influenza Mutations' Pandemic Potential July 7, 2017A new technique labels gene segments to help understand how the virus enters a cell and establishes co-infections.
BioTM Articles Topping Altmetrics Charts June 27, 2017In its first year, BioTM is already topping the charts, with top ratings for viewing, sharing, and discussion of articles.
Technical Entity Trends: A World Transitioning to Translational Medicine June 2, 2017The failure rate for new drugs and therapies under development exceeds 95%.
Could Caribbean Snail Battle Opioid Addiction? February 27, 2017A compound found in a snail's venom yields pain-fighting effects in testing, presenting a possible opioid alternative.
Nanostraw Tool Samples Cells without Destruction February 23, 2017Using nanostraws, scientists can now sample cell contents without disrupting a cell's natural processes.