Genome Editing

The Untapped Information of the Epigenome

September
2018
SBE Special Section
Albert J. Keung
The complexity of the epigenome suggests a wealth of untapped biological information and regulatory potential that could be game changing for cellular engineering and biomedical interventions.

Unlocking Access to DNA in Chromatin

September
2018
SBE Special Section
Cassandra M. Barrett, Karmella A. Haynes
Scientists must learn how to open and manipulate chromatin to gain complete access to eukaryotic DNA for genome engineering.

Epigenetics: Making a Mark

September
2018
SBE Special Section
Gabriel Levesque-Tremblay
The epigenome is composed of modifications to DNA that determine which genes of the genome are expressed or suppressed without changing the DNA sequence.

Influence of Epigenetics on Bioprocessing

September
2018
SBE Special Section
Mark Blenner
Harnessing and applying epigenetics in bioprocessing systems may improve cell line development, productivity, and product quality.

Single-Cell Epigenomic Technology and Applications

September
2018
SBE Special Section
Chongli Yuan, Li Lin, Ana Carneiro, Junkai Xie
This article highlights developments in single-cell epigenomic monitoring and modulating tools, as well as advances in synthetic epigenetic circuits. These tools are used in important biomedical and industrial applications.

CEP: News Update

August
2018
News Update
New CRISPR Findings Raise Concerns Before Technology’s Clinical Debut A pair of studies that investigated the effect of CRISPR-Cas 9 on a key protein that regulates cell growth and protects against cancer has sent shockwaves through the growing...

Technical Entity Trends: CRISPR: Editing Genes One Sequence at a Time

June
2018
Technical Entity Trends
Keith Joseph
The technology known as CRISPR — clustered regularly interspaced short palindromic repeats — has taken the field of synthetic bioengineering by storm. It emerged as a gene-editing tool only five years ago, but has become a familiar presence in the lab.

First Complete Human Genome within Sight

March 20, 2018

Researchers announced this week that they are closing in on producing the first complete and accurate linear map of a human Y chromosome centromere.

CEP: News Update

March
2018
News Update
Vaccine Boosts Immune System Response to Cancer Cancer can be difficult to treat because its highly proliferative cells spread throughout the body, effectively evading the immune system’s surveillance. One opportunity that scientists are pursuing...

Your Experiences Leave a Mark

February 13, 2018

Epigenetics — the study of how our actions and experiences mark or modify our DNA — can explain some unusual genetic findings.

CEP: News Update

January
2018
News Update
New Technique 3D Prints Living Materials Although most 3D printers produce objects from inorganic matter, an international team of scientists has developed a way for their prints to take on a life of their own. Engineers Put Two-Dimensional...
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