Development of Next Generation Purification Platforms through Novel Technologies and Holistic Process Engineering Approaches Archived Webinar May 2, 2018 How can you address new requirements to shrink time to clinic and decrease biopharmaceutical manufacturing cost and risk? Take this webinar to find out. Join 3M’s, Alexei Voloshin, as he discusses...
Small Proteins Seen in Near-Atomic Detail April 17, 2018UCLA biochemists have harnessed cryo-electron microscopy to see near-atomic detail in much smaller proteins than ever before.
Misfolded and Aggregated Proteins Draw New Attention March 21, 2018Once a non-topic, misfolded and aggregated proteins are drawing a lot of attention, and an article that singles out high-quality publications on these topics is in the spotlight.
Efficient Detection of Amyloida using PMMA-Tag Fused VHH Antibody Conference PresentationAIChE Annual MeetingNovember 10, 2015VHH domains represent the smallest antigen-binding unit with a molecular size of∼15 kDa in comparison to scFv fragments (30 kDa), Fab fragments (...
Optimization of the Protein Pegylation Process Conference PresentationAIChE Annual MeetingNovember 20, 2014
Self-Assembled Peptide Amphiphile Micelles Improve Group a Streptococcal Vaccination Conference PresentationAIChE Annual MeetingNovember 18, 2014Streptococcus pyogenes (Group A Streptococcus, GAS) is a Gram-positive bacterium restricted to natural growth in humans where it frequently elicits...
Revealing a Stimulatory Effect of Lignin in Enzymatic Hydrolysis of Lignocellulose Conference PresentationAIChE Annual MeetingNovember 17, 2014The electrostatic and hydrophobic interactions between cellulases and lignin play essential roles in enzymatic hydrolysis of lignocellulsoic...
Single Use Centrifuge- CHO Clarification Conference PresentationAIChE Annual MeetingNovember 7, 2013Abstract Text: The large scale economic collection of proteins is an important problem for the Biotechnology industry. Generally , proteins are...
Model Based Development and Validation of a Preparative Size Exclusion Chromatography Step Conference PresentationAIChE Annual MeetingNovember 5, 2013Model based development and validation of a preparative Size Exclusion Chromatography step Ernst B. Hansen , Thomas B. Hansen and Lars Sejergaard...
The Interactions of the Corn Protein Zein and Ionic Liquids Conference PresentationAIChE Annual MeetingNovember 5, 2013The solubility and secondary structure of the hydrophobic corn protein zein in ionic liquids was studied as a function of temperature and solvent...
Complex Fitness Diagrams and Downstream Processing Conference PresentationAIChE Annual MeetingNovember 5, 2013Focus here is development of production scale processes and specifically with modifying optimized laboratory processes that are unsuitable for large-...
Biobased Materials (Plant Proteins) As Alternatives for Suspected Carcinogens and Other Hazardous Chemicals in Large-Scale Manufacturing Processes Conference PresentationAIChE Spring Meeting and Global Congress on Process SafetyApril 3, 2012Biobased Materials (Plant Proteins) as Alternatives for Suspected Carcinogens and other Hazardous Chemicals in Large-Scale Manufacturing Processes
New Technologies from Engineered Chimeric Proteins Archived Webinar Mar 21, 2011 We engineer designer fusion proteins that combine domains and functions from unrelated proteins and enzymes. In bioseparations, we have combined a previously developed pH-sensitive self-cleaving...
Carbohydrate Circle and Genetic Information Flow Studies of Escherichia Coli Reveal the Molecular Mechanisms of Resistance to Balofloxacin Conference PresentationAIChE Annual MeetingNovember 10, 2010Protein-protein interactions are pivotal in many biological processes and essential for a global understanding of cell functions. In the present...
A Comprehensive Profiling of Genome-Wide Transcriptional Programs of Primary Hepatocytes in Vitro Cultures Conference PresentationAIChE Annual MeetingNovember 8, 2010The liver is one of most important organs in our bodies and performs many essential functions including metabolism, synthesis, secretion,...
Modeling Eukaryotic Unfolded Protein Response and Its Role in Cellular Stress Conference PresentationAIChE Annual MeetingNovember 7, 2010Malfunctions in the folding state of critical proteins have been linked with cancer, diabetes and other diseases. Proteins requiring complex post-...
Modular Biocatalysis Archived Webinar Jun 29, 2010 Modularity is a highly sought after feature in engineering design. A modular catalyst is a multi-component system whose parts can be predictably interchanged for functional flexibility and variety...
Breaking the Cell Wall Barrier for Difficult-to-Express Natural and Supernatural Products Archived Webinar May 27, 2010 Modern recombinant DNA expression technologies, by definition, challenge cells to engage in unnatural acts; specifically, the production of new types and large quantities of proteins for which the...
Computational Protein Engineering October2017SBE Special SectionRobert PantazesProteins could transform the chemical process industries if they could be engineered to facilitate the production of biofuels, molecular medicines, and other specialty chemicals. This reality is nearing as expanded knowledge of proteins and improvements in computational tools are making it possible to design specific protein structures and functions.
SBE Special Section: Biomolecular Engineering (full 34-page section) October2017SBE Special SectionSBE Update: The Many Applications of Biomolecular Engineering; A Materials Approach to Vaccines as Therapies; Engineering Cancer-Fighting T Cells; There's Plenty of Room at the Botton of a Cell; Computational Protein Engineering; Plant Metabolic Engineering for Chemicals, Fuels, and Precursors
Micro Silk Cocoons Could Be Used in Food and Medicine July 19, 2017Microscopic versions of silkworm cocoons that could be used to protect sensitive molecular materials.
Enzyme Destroys Biofilm of Multiple Organisms June 26, 2017Instead of targeting individual microbes, researchers went after the biofilm that protects them and found great success.
Nanostraw Tool Samples Cells without Destruction February 23, 2017Using nanostraws, scientists can now sample cell contents without disrupting a cell's natural processes.
Anti-Apoptotic Proteins Undervalued in Search for Cancer Therapies December 12, 2016Researchers at the University of California, Riverside, recently published work that suggests that the usefulness of studying pro- and anti-apoptotic proteins in a search for cancer
Synthetic DNA Could Redefine Drug Design September 15, 2016A startup in southern California is designing microbes that extend DNA beyond the natural A, T, G, and C components to include X and Y.
Possible Path to Vaccine for Flesh-Eating Bacteria September 7, 2016It sounds like something straight out of a science fiction movie: bacteria that feeds on human flesh.
Team Stores 200 MB of Data on DNA Strands July 12, 2016With increasingly large volumes of data being created every day, the search for stable and compact data storage has turned to DNA to replace the relatively fragile magnetic backups that are today
Major Public Database to Fuel Personalized Medicine July 8, 2016The U.S. government announced this week that it is putting aside $55 million to create a public database with health information on about one million volunteers.
Interview: Wilfred Chen on Adding Logic to Complex Protein Functions November 10, 2015The 2015 D.I.C.
Creating an Internet for Genomic Information December 24, 2014A group called the Global Alliance for Genomics and Health (known as the Global Alliance) wants to maximize the use of genetic
Computer Simulations Unlock Molecular Cell Membrane December 22, 2014Just a few days ago, an article appeared in the journal Science announcing a major breakthrough: artificial transporter proteins that can carry individual atoms across the membrances th
Renowned Scientist and AIChE Member Frances Arnold Profiled on NPR December 17, 2014Any short list of cutting-edge engineers will likely include Caltech’s Frances Arnold, a pioneer in protein engineeri
Catalyzing Commercialization: New Process Makes Spider Silk in Many Forms August2016Catalyzing CommercializationThe strongest fiber found in nature is a silk made by spiders known as orb weavers. Unfortunately, spiders have two flaws: They are territorial and cannibalistic, making it impossible to farm them like silkworms to produce massive quantities of silk...
Detection of Process Fingerprints Applying Multivariate Analysis Methods to Monoclonal Antibody Cell Culture Data Conference PresentationAIChE Annual MeetingNovember 19, 2014This work presents a sequential data analysis path, which was successfully applied to identify process characteristics in fed-batch cultivation data...
Your Personal Genome for $1,000? November2009SBE Special SectionIBM scientists from four fields — nanofabrication, microelectronics, physics and biology — are collaborating to develop a “DNA transistor” that could make obtaining a personalized genome analysis easier, faster, and cheaper — ultimately as low as $...
Purifying Therapeutic Monoclonal Antibodies May2008SBE Special SectionJace Fogle, Nuno Fontes, Benedicte Lebreton, Amy Len, Amit Mehta, Robert van Reis, Roshan Shrestha, Martha Lovato Tse, Bradley WolkEliminating the affinity chromatography step in the mAb purification process trims equipment requirements, shrinks the plant footprint— and reduces costs.