Enzyme Destroys Biofilm of Multiple Organisms June 26, 2017Instead of targeting individual microbes, researchers went after the biofilm that protects them and found great success.
New Technologies from Engineered Chimeric Proteins Archived Webinar Mar 21, 2011 We engineer designer fusion proteins that combine domains and functions from unrelated proteins and enzymes. In bioseparations, we have combined a previously developed pH-sensitive self-cleaving protein with a variety of purification tags to produce simple and economical methods for purifying...
Modular Biocatalysis Archived Webinar Jun 29, 2010 Modularity is a highly sought after feature in engineering design. A modular catalyst is a multi-component system whose parts can be predictably interchanged for functional flexibility and variety. Over the past two decades, much of the research in our laboratory has focused on understanding the...
Breaking the Cell Wall Barrier for Difficult-to-Express Natural and Supernatural Products Archived Webinar May 27, 2010 Modern recombinant DNA expression technologies, by definition, challenge cells to engage in unnatural acts; specifically, the production of new types and large quantities of proteins for which the cells have not evolved. Consequently, many natural products are toxic, do not fold properly, or do not...
Nanostraw Tool Samples Cells without Destruction February 23, 2017Using nanostraws, scientists can now sample cell contents without disrupting a cell's natural processes. The new tool was developed by researchers at Stanford, and it is hoped...
Anti-Apoptotic Proteins Undervalued in Search for Cancer Therapies December 12, 2016Researchers at the University of California, Riverside, recently published work that suggests that the usefulness of studying pro- and anti-apoptotic proteins in a search for...
Major Public Database to Fuel Personalized Medicine July 8, 2016The U.S. government announced this week that it is putting aside $55 million to create a public database with health information on about one million volunteers.
Team Stores 200 MB of Data on DNA Strands July 12, 2016With increasingly large volumes of data being created every day, the search for stable and compact data storage has turned to DNA to replace the relatively fragile magnetic...
Advanced X-Ray Jump Starts Drug Design January 24, 2012The anti-cancer drug Zelboraf (vemurafenib) recently received FDA approval, but it was front page news when the drug, designed to disrupt malignant melanoma, was so successful...
Possible Path to Vaccine for Flesh-Eating Bacteria September 7, 2016It sounds like something straight out of a science fiction movie: bacteria that feeds on human flesh. But the highly infection bacteria know has group A Streptococcu s is capable...
Renowned Scientist and AIChE Member Frances Arnold Profiled on NPR December 17, 2014Any short list of cutting-edge engineers will likely include Caltech’s Frances Arnold , a pioneer in protein engineering. In specific, she specializes in a method that mimics the...
Synthetic DNA Could Redefine Drug Design September 15, 2016A startup in southern California is designing microbes that extend DNA beyond the natural A, T, G, and C components to include X and Y.
Computer Simulations Unlock Molecular Cell Membrane December 22, 2014Just a few days ago, an article appeared in the journal Science announcing a major breakthrough: artificial transporter proteins that can carry individual atoms across the...
Creating an Internet for Genomic Information December 24, 2014A group called the Global Alliance for Genomics and Health (known as the Global Alliance ) wants to maximize the use of genetic data by creating a responsible way to share it with...
Interview: Wilfred Chen on Adding Logic to Complex Protein Functions November 10, 2015The 2015 D.I.C. Wang Award for Excellence in Biochmical Engineering was presented by Wilfred Chen. Professor Wilfred Chen joined the University of Delaware in January 1, 2011 as...
Biobased Materials (Plant Proteins) As Alternatives for Suspected Carcinogens and Other Hazardous Chemicals in Large-Scale Manufacturing Processes Conference PresentationAIChE Spring Meeting and Global Congress on Process SafetyApril 3, 2012Biobased Materials (Plant Proteins) as Alternatives for Suspected Carcinogens and other Hazardous Chemicals in Large-Scale Manufacturing Processes
Catalyzing Commercialization: New Process Makes Spider Silk in Many Forms August2016Catalyzing CommercializationThe strongest fiber found in nature is a silk made by spiders known as orb weavers. Unfortunately, spiders have two flaws: They are territorial and cannibalistic, making it impossible to farm them like silkworms to produce massive quantities of silk...
Efficient Detection of Amyloida using PMMA-Tag Fused VHH Antibody Conference PresentationAIChE Annual MeetingNovember 10, 2015VHH domains represent the smallest antigen-binding unit with a molecular size of∼15 kDa in comparison to scFv fragments (30 kDa), Fab fragments (60...
Optimization of the Protein Pegylation Process Conference PresentationAIChE Annual MeetingNovember 20, 2014
Detection of Process Fingerprints Applying Multivariate Analysis Methods to Monoclonal Antibody Cell Culture Data Conference PresentationAIChE Annual MeetingNovember 19, 2014This work presents a sequential data analysis path, which was successfully applied to identify process characteristics in fed-batch cultivation data...
Self-Assembled Peptide Amphiphile Micelles Improve Group a Streptococcal Vaccination Conference PresentationAIChE Annual MeetingNovember 18, 2014Streptococcus pyogenes(Group A Streptococcus, GAS) is a Gram-positive bacterium restricted to natural growth in humans where it frequently elicits...
Revealing a Stimulatory Effect of Lignin in Enzymatic Hydrolysis of Lignocellulose Conference PresentationAIChE Annual MeetingNovember 17, 2014The electrostatic and hydrophobic interactions between cellulases and lignin play essential roles in enzymatic hydrolysis of lignocellulsoic...
Single Use Centrifuge- CHO Clarification Conference PresentationAIChE Annual MeetingNovember 7, 2013Abstract Text: The large scale economic collection of proteins is an important problem for the Biotechnology industry. Generally , proteins are...
Model Based Development and Validation of a Preparative Size Exclusion Chromatography Step Conference PresentationAIChE Annual MeetingNovember 5, 2013Model based development and validation of a preparative Size Exclusion Chromatography step Ernst B. Hansen , Thomas B. Hansen and Lars Sejergaard...
The Interactions of the Corn Protein Zein and Ionic Liquids Conference PresentationAIChE Annual MeetingNovember 5, 2013The solubility and secondary structure of the hydrophobic corn protein zein in ionic liquids was studied as a function of temperature and solvent...
Complex Fitness Diagrams and Downstream Processing Conference PresentationAIChE Annual MeetingNovember 5, 2013Focus here is development of production scale processes and specifically with modifying optimized laboratory processes that are unsuitable for large-...
Carbohydrate Circle and Genetic Information Flow Studies of Escherichia Coli Reveal the Molecular Mechanisms of Resistance to Balofloxacin Conference PresentationAIChE Annual MeetingNovember 10, 2010Protein-protein interactions are pivotal in many biological processes and essential for a global understanding of cell functions. In the present...
A Comprehensive Profiling of Genome-Wide Transcriptional Programs of Primary Hepatocytes in Vitro Cultures Conference PresentationAIChE Annual MeetingNovember 8, 2010The liver is one of most important organs in our bodies and performs many essential functions including metabolism, synthesis, secretion,...
Modeling Eukaryotic Unfolded Protein Response and Its Role in Cellular Stress Conference PresentationAIChE Annual MeetingNovember 7, 2010Malfunctions in the folding state of critical proteins have been linked with cancer, diabetes and other diseases. Proteins requiring complex post-...
Purifying Therapeutic Monoclonal Antibodies May2008SBE Special SectionJace Fogle, Nuno Fontes, Benedicte Lebreton, Amy Len, Amit Mehta, Robert van Reis, Roshan Shrestha, Martha Lovato Tse, Bradley WolkEliminating the affinity chromatography step in the mAb purification process trims equipment requirements, shrinks the plant footprint— and reduces costs.
Your Personal Genome for $1,000? November2009SBE Special SectionIBM scientists from four fields — nanofabrication, microelectronics, physics and biology — are collaborating to develop a “DNA transistor” that could make obtaining a personalized genome analysis easier, faster, and cheaper — ultimately as low as $...