Protein Engineering

New Technologies from Engineered Chimeric Proteins

Archived Webinar
Mar 21, 2011
We engineer designer fusion proteins that combine domains and functions from unrelated proteins and enzymes. In bioseparations, we have combined a previously developed pH-sensitive self-cleaving protein with a variety of purification tags to produce simple and economical methods for purifying...

Modular Biocatalysis

Archived Webinar
Jun 29, 2010
Modularity is a highly sought after feature in engineering design. A modular catalyst is a multi-component system whose parts can be predictably interchanged for functional flexibility and variety. Over the past two decades, much of the research in our laboratory has focused on understanding the...

Nanostraw Tool Samples Cells without Destruction

February 23, 2017
Using nanostraws, scientists can now sample cell contents without disrupting a cell's natural processes. The new tool was developed by researchers at Stanford, and it is hoped...

Team Stores 200 MB of Data on DNA Strands

July 12, 2016
With increasingly large volumes of data being created every day, the search for stable and compact data storage has turned to DNA to replace the relatively fragile magnetic...

Advanced X-Ray Jump Starts Drug Design

January 24, 2012
The anti-cancer drug Zelboraf (vemurafenib) recently received FDA approval, but it was front page news when the drug, designed to disrupt malignant melanoma, was so successful...

Possible Path to Vaccine for Flesh-Eating Bacteria

September 7, 2016
It sounds like something straight out of a science fiction movie: bacteria that feeds on human flesh. But the highly infection bacteria know has group A Streptococcu s is capable...

Creating an Internet for Genomic Information

December 24, 2014
A group called the Global Alliance for Genomics and Health (known as the Global Alliance ) wants to maximize the use of genetic data by creating a responsible way to share it with...

Catalyzing Commercialization: New Process Makes Spider Silk in Many Forms

August
2016
Catalyzing Commercialization
The strongest fiber found in nature is a silk made by spiders known as orb weavers. Unfortunately, spiders have two flaws: They are territorial and cannibalistic, making it impossible to farm them like silkworms to produce massive quantities of silk...

Single Use Centrifuge- CHO Clarification

Conference Presentation
AIChE Annual Meeting
November 7, 2013
Abstract Text: The large scale economic collection of proteins is an important problem for the Biotechnology industry. Generally , proteins are...

Complex Fitness Diagrams and Downstream Processing

Conference Presentation
AIChE Annual Meeting
November 5, 2013
Focus here is development of production scale processes and specifically with modifying optimized laboratory processes that are unsuitable for large-...

Purifying Therapeutic Monoclonal Antibodies

May
2008
SBE Special Section
Jace Fogle, Nuno Fontes, Benedicte Lebreton, Amy Len, Amit Mehta, Robert van Reis, Roshan Shrestha, Martha Lovato Tse, Bradley Wolk
Eliminating the affinity chromatography step in the mAb purification process trims equipment requirements, shrinks the plant footprint— and reduces costs.

Your Personal Genome for $1,000?

November
2009
SBE Special Section
IBM scientists from four fields — nanofabrication, microelectronics, physics and biology — are collaborating to develop a “DNA transistor” that could make obtaining a personalized genome analysis easier, faster, and cheaper — ultimately as low as $...
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