Protein Engineering

Single Use Centrifuge- CHO Clarification

Conference Presentation
AIChE Annual Meeting
November 7, 2013
Abstract Text: The large scale economic collection of proteins is an important problem for the Biotechnology industry. Generally , proteins are...

Complex Fitness Diagrams and Downstream Processing

Conference Presentation
AIChE Annual Meeting
November 5, 2013
Focus here is development of production scale processes and specifically with modifying optimized laboratory processes that are unsuitable for large-...

New Technologies from Engineered Chimeric Proteins

Archived Webinar
Mar 21, 2011
We engineer designer fusion proteins that combine domains and functions from unrelated proteins and enzymes. In bioseparations, we have combined a previously developed pH-sensitive self-cleaving protein with a variety of purification tags to produce simple and economical methods for purifying...

Modular Biocatalysis

Archived Webinar
Jun 29, 2010
Modularity is a highly sought after feature in engineering design. A modular catalyst is a multi-component system whose parts can be predictably interchanged for functional flexibility and variety. Over the past two decades, much of the research in our laboratory has focused on understanding the...

Computational Protein Engineering

October
2017
SBE Special Section
Robert Pantazes
Proteins could transform the chemical process industries if they could be engineered to facilitate the production of biofuels, molecular medicines, and other specialty chemicals. This reality is nearing as expanded knowledge of proteins and improvements in computational tools are making it possible to design specific protein structures and functions.

SBE Special Section: Biomolecular Engineering (full 34-page section)

October
2017
SBE Special Section
SBE Update: The Many Applications of Biomolecular Engineering; A Materials Approach to Vaccines as Therapies; Engineering Cancer-Fighting T Cells; There's Plenty of Room at the Botton of a Cell; Computational Protein Engineering; Plant Metabolic Engineering for Chemicals, Fuels, and Precursors

Team Stores 200 MB of Data on DNA Strands

July 12, 2016

With increasingly large volumes of data being created every day, the search for stable and compact data storage has turned to DNA to replace the relatively fragile magnetic backups that are today's

Computer Simulations Unlock Molecular Cell Membrane

December 22, 2014

Just a few days ago, an article appeared in the journal Science announcing a major breakthrough: artificial transporter proteins that can carry individual atoms across the membrances that pr

Catalyzing Commercialization: New Process Makes Spider Silk in Many Forms

August
2016
Catalyzing Commercialization
The strongest fiber found in nature is a silk made by spiders known as orb weavers. Unfortunately, spiders have two flaws: They are territorial and cannibalistic, making it impossible to farm them like silkworms to produce massive quantities of silk...

Your Personal Genome for $1,000?

November
2009
SBE Special Section
IBM scientists from four fields — nanofabrication, microelectronics, physics and biology — are collaborating to develop a “DNA transistor” that could make obtaining a personalized genome analysis easier, faster, and cheaper — ultimately as low as $...

Purifying Therapeutic Monoclonal Antibodies

May
2008
SBE Special Section
Jace Fogle, Nuno Fontes, Benedicte Lebreton, Amy Len, Amit Mehta, Robert van Reis, Roshan Shrestha, Martha Lovato Tse, Bradley Wolk
Eliminating the affinity chromatography step in the mAb purification process trims equipment requirements, shrinks the plant footprint— and reduces costs.
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