SBE Special Section: Biopharmaceuticals - SBE Update: Continuous Progress in Biopharmaceuticals


The goal of bioprocessing is to optimize natural or artificial biological systems by manipulating prokaryotic and eukaryotic cells and their environment to produce biopharmaceutical products. A bioprocess is divided into upstream and downstream operations. Upstream processing encompasses the steps from preliminary unmodified cell line culture to the mature modified cell culture and harvest; downstream processing includes the separation and purification of the biologics from the mature activated cell culture. These operations have typically been performed as batch processes.

The authors of this supplement’s second article explain the transition to continuous processing in the manufacture of biopharmaceuticals: “While continuous downstream processing...

Author Bios: 

Darlene Schuster

Darlene Schuster serves as the Executive Director of the Institute for Sustainability, an AIChE Technological Community, where she oversees the industry, membership and youth-focused entities formed to advance the science and state of sustainability and the creation of the AIChE Sustainability Index (sm), a benchmark for industry. She also staffs the new AIChE Center for Energy Initiatives.

Dr. Schuster was the Clare Boothe Luce Chair of Chemical Engineering at Bucknell University, and held various engineering positions with Gulf Oil Production Research and Chevron Oil Field...Read more

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