SBE Special Section: Biopharmaceuticals - SBE Update: Continuous Progress in Biopharmaceuticals


The goal of bioprocessing is to optimize natural or artificial biological systems by manipulating prokaryotic and eukaryotic cells and their environment to produce biopharmaceutical products. A bioprocess is divided into upstream and downstream operations. Upstream processing encompasses the steps from preliminary unmodified cell line culture to the mature modified cell culture and harvest; downstream processing includes the separation and purification of the biologics from the mature activated cell culture. These operations have typically been performed as batch processes.

The authors of this supplement’s second article explain the transition to continuous processing in the manufacture of biopharmaceuticals: “While continuous downstream processing...

Author Bios: 

Darlene Schuster

Darlene Schuster is responsible for the successful implementation of AIChE conferences, publications,  educational AIChE Academy, membership programs and membership groups, and growth of AIChE impact to serve members in areas of relevance to chemical engineering.  Previously she was the executive director of the Technical Entities of AIChE, including the Institute for Sustainability, Society for Biological Engineering, the International Society for Metabolic Engineering, and the start-up entities. Schuster joined AIChE as director of government relations and headed AIChE’s...Read more

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