CEP: December 2015 This SBE supplement covers the development of continuous processing techniques in upstream and downstream biopharmaceutical processes. It also details factors that are impeding end-to-end implementation of continuous biopharmaceutical manufacturing processes, and points out that despite some misconceptions, regulators such as the U.S. Food and Drug Administration (FDA), encourage, rather than prevent, continuous processing. Other topics in this issue include cyclic ditillation and France's chemical industry. Editorial A Vote for Science and Engineering Even though the election of a new U.S. President is almost a year away, it’s hard to ignore the news media’s extensive coverage of the many candidates — their debates, their campaign speeches, their experience; almost anything they do or say is fair game for the press. However, science and engineering, for the most part, have gotten less attention than issues such as the economy, immigration, health care, homeland security, and gun control. Read more Share Revive Your Columns with Cyclic Distillation December2015Reactions and SeparationsCostin Sorin Bîldea, Anton A. KissThis process intensification technique involves changing a tower’s internals and operating mode and the separate movement of the liquid and vapor phases. This can significantly increase column throughput and reduce energy requirements, while improving separation performance. France’s Chemicals Industry is Rooted in Tradition December2015Global OutlookDidier Le VélyFrance played a central role in the chemistry revolution and now has a leading role in the modern chemicals industry. Manufacturing a wide range of chemicals, from basics and specialties to fine chemicals for pharmaceuticals, the industry is a major contributor to France’s economy. SBE Special Section: Biopharmaceuticals - SBE Update: Continuous Progress in Biopharmaceuticals December2015SBE Special SectionDarlene SchusterThe goal of bioprocessing is to optimize natural or artificial biological systems by manipulating prokaryotic and eukaryotic cells and their environment to produce biopharmaceutical products. A bioprocess is divided into upstream and downstream operations. Upstream processing encompasses the steps from preliminary unmodified cell line culture to the mature modified cell culture and harvest; downstream processing includes the separation and purification of the biologics from the mature activated cell culture. These operations have typically been performed as batch processes. SBE Special Section: Biopharmaceuticals - Meet the Authors December2015SBE Special Section SBE Special Section: Biopharmaceuticals - Continuous Processing in Upstream Operations December2015SBE Special SectionChun Chen, Chetan T. Goudar, Huong LePerfusion technology offers many benefits over fed-batch processing, such as reducing the size of the bioreactor, which reduces capital costs and enables the use of single-use bioreactor technology. Despite these advantages, a shift to continuous perfusion will likely be gradual. SBE Special Section: Biopharmaceuticals - Continuous Processing in Downstream Operations December2015SBE Special SectionTodd Przybycien, Professor Nigel Titchener-HookerThe transition from batch to continuous downstream processing of biologics has been gradual, with some processes integrating continuous and batch operations. A fully continuous, commercial-scale downstream process has yet to be implemented. Find out why, as well as the current status of the technology. SBE Special Section: Biopharmaceuticals - A Look at the Regulations December2015SBE Special SectionElizabeth PavoneWhat is impeding implementation of continuous processes in biopharmaceutical manufacturing? Not the regulations. SBE Special Section: Biopharmaceuticals (Full 19-Page Supplement) December2015SBE Special SectionChun Chen, Chetan T. Goudar, Huong Le, Todd Przybycien, Nigel Titchener-HookerSBE Update: Continuous Progress in Biopharmaceuticals; Continuous Processing in Upstream Operations; Continuous Processing in Downstream Operations; A Look at the Regulations Copyright Permissions: Would you like to reuse content from CEP Magazine? It’s easy to request permission to reuse content. Simply click here to connect instantly to licensing services, where you can choose from a list of options regarding how you would like to reuse the desired content and complete the transaction.