Crumbling Genome: The Impact of Deleterious Mutations on Humans
Alexey S. Kondrashov, Wiley-Blackwell, Hoboken, NJ, $99.95, 296 pages, July 2017, ISBN: 978-1-118-95211-5
A newborn human carries approximately 100 new mutations, originating in their parents, of which 10 are deleterious. A mutation that replaces just one of the more than three billion nucleotides in the human genome can result in tragic diseases. Milder, but still substantial, negative effects of mutations are even more pervasive. There is currently no way to reduce the rate of spontaneous mutations. However, a recent flood of genomic data, made possible by new methods of DNA sequencing, has enabled scientists to explore the impacts of deleterious mutations on humans and develop approaches to managing them.
Written for those in the biological sciences, as well as for readers with a general interest in science and genetics, this book reviews our current knowledge of deleterious mutations and their effects on humans. It includes an extensive introduction to the...
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