Metabolic Engineering 12 - Technical Program

ME-12 Preliminary Technical Program

Please note that this schedule is subject to change. Check back frequently for updates.

Last updated: 18-June-2018

Browse Detailed Preliminary Program here

Sunday, June 24, 2018

 

2:30 PM - 7:00 PM Registration  
4:45 PM - 5:30 PM Opening Reception &
Poster Session (Group I)
 
5:30 PM - 6:15 PM Plenary Presentation: Enzymes by Evolution: Bringing New Chemistry to Life Frances Arnold, California Institute of Technology, USA
6:15 PM- 7:00 PM Plenary Presentation: Challenges of the Biotech Industry- Growing with Innovation Martin Brudermüller, BASF SE, Germany
7:00 PM - 7:45 PM Opening Reception & Poster Session (continued)  
7:45 PM - 9:00 PM Dinner  

 

Monday, June 25, 2018

7:00 AM - 12:00 PM Registration  
8:00 AM - 8:10 AM Opening Ceremony  
8:10 AM - 10:20 AM Session 1:  Systems Biology and Multi-Omics Insights
Chair: Hiroshi Shimizu, Osaka University, Japan
Chair: Costas Maranas, Pennsylvania State University, USA
 
8:10 AM - 8:50 AM Keynote Presentation: Systems Biology of Yeast Metabolism Jens Nielsen, Chalmers University, Sweden
8:50 AM - 9:15 AM Invited Presentation: Metabolic Coordination through Metabolite-Protein Interactions Uwe Sauer, ETH Zurich, Switzerland
9:15 AM - 9:40 AM Invited Presentation: Deciphering Whole Cell Responses Using Top-Down and Bottom-Up Approaches Bernhard Palsson, University of California, San Diego, USA
9:40 AM - 10:00 AM Synthetic & Natural C1 Metabolism: From in silico Design to In Vivo Validation Stéphanie Heux, Toulouse University, France
10:00 AM - 10:20 AM Move Identifies Metabolic Valves to Switch between Phenotypic States Radhakrishnan Mahadevan, University of Toronto, Canada
10:20 AM - 10:50 AM Coffee Break  
10:50 AM- 1:00 PM Session 2: Synthetic Biology and Genome Editing 
Chair: Verena Siewers, Chalmers University, Sweden
Chair: Elena Brevnova, Ginkgo Bioworks, USA
 
10:50 AM- 11:30 AM Keynote Presentation: Engineered Autonomous Control of Metabolic Pathways Kristala Jones Prather, Massachusetts Institute of Technology, USA
11:30 AM- 11:55 AM Invited Presentation: Synthetic Biology Tools to Control Carbon Flux and Couple Production to Bioprocess Condition: Isoprenoids As a Model System Claudia Vickers, University of Queensland, Australia
11:55 AM- 12:20 PM Invited Presentation:  Christopher Voigt, Massachusetts Institute of Technology, USA
12:20 PM- 12:40 PM Casper: Algorithms and Integrated Software Platform for Precise CRISPR Genome Editing of Single and Consortia of Organisms Cong Trinh, University of Tennessee, USA
12:40 PM- 1:00 PM Phylogenetically Diversified Multi-Chassis Engineering Enables Rapid Activation of Biosynthetic Gene Clusters Yasuo Yoshikuni , Lawrence Berkeley National Laboratory, USA
1:00 PM - 2:10 PM Lunch  
2:10 PM - 4:50 PM Session 3: Metabolic Engineering Concepts      
Chair: Philippe Soucaille, INSA Toulouse, France
Chair: Mattheos Koffas, Rensselaer Polytechnic Institute, USA
 
2:10 PM - 2:50 PM Keynote Presentation: Next Generation High-Throughput Technologies for Microbial Strain Development Michael Lynch, Duke University, USA
2:50 PM - 3:15 PM Invited Presentation: Metabolic Engineering Meets Evolution: New Approaches for the Optimization and Selection of Metabolic Phenotypes Hal Alper, University of Texas at Austin, USA
3:15 PM - 3:45 PM Coffee Break  
3:45 PM - 4:10 PM Invited Presentation: From Plastic Waste to Plastic Value Using Pseudomonas Putida Lars Blank, RWTH Aachen University, German
4:10 PM - 4:30 PM Combining Automation, Analytics, and Databasing to Build an Integrated Adaptive Evolution Platform  Adam Feist, University of California, San Diego, USA
4:30 PM - 4:50 PM Expanding the Space of Actual Metabolic Network in Escherichia coli by Adaptive Laboratory Evolution Hiroshi Shimizu, Osaka University, Japan
4:50 PM - 5:50 PM

Rapid Fire Poster Presentation

Chair: Hal Alper, University of Texas at Austin, USA

 
5:50 PM - 7:30 PM Poster Session (Group I) and Reception  
7:30 PM - 9:30 PM Bavarian Evening  

 

Tuesday, June 26, 2018

7:00 AM - 12:00 PM Registration  
8:00 AM - 10:10 AM Session 4: Design and Assembly of Metabolic Pathways
Chair: Si Jae Park, Ewha Womans University, South Korea
Chair: Lars Blank, RWTH Aachen University, Germany
 
8:00 AM - 8:40 AM Keynote Presentation: Engineering Commensal Microbes to Rewire Host-Microbiome Interactions Matthew Chang, National Universtiy of Singapore, Singapore
8:40 AM - 9:05 AM Invited Presentation: Targeted Synthetic Metabolism for Overprodcution of Natral Products to Meet the Industrilization Tiangang Liu, Wuhan University, China
9:05 AM - 9:30 AM Invited Presentation: Systemic Analysis and Metabolic Engineering of Gluconobacter Oxydans, a Host for Oxidative Biotransformations Michael Bott, Research Centre Jülich, Germany
9:30 AM - 9:50 AM Optimization-Based Algorithm for the Design of Thermodynamically Feasible and Kinetically Efficient Metabolic Pathways   Pedro Saa, University of Chile, Chile
9:50 AM - 10:10 AM Multienzyme Assembly-Assisted Terpenoid Biosynthesis    Jiang Xia, The Chinese University of Hong Kong, Hong Kong 
10:10 AM - 10:40 AM Coffee Break  
10:40 AM- 12:50 PM Session 5: Metabolic Engineering of Microorganisms
Chair: George Chen, Tsinghua University, China
Chair: Julia Frunzke, Forschungszentrum Jülich, Germany
 
10:40 AM- 11:20 AM Keynote Presentation: Synthetic Biology Platforms for Plant Natural Product Biosynthesis and Discovery Christina Smolke, Stanford University, USA
11:20 AM- 11:45 AM Invited Presentation: Debottlenecking Glycerol Utilization in Saccharomyces Cerevisiae Elke Nevoigt, Jacobs University of Bremen, Germany
11:45 AM- 12:10 PM Invited Presentation: Synthetic Syntrophy with CO2 Fixation Enables Complete and Efficient Carbon and Electron Utilization for Metabolite Production and Expands the Metabolite Space Eleftherios Terry Papoutsakis, University of Delaware, USA
12:10 PM- 12:30 PM Exploiting the Potential of Unconventional Yeast Yarrowia Lipolytica for Metabolic Engineering  Qingsheng Qi, Shandong University, China
12:30 PM- 12:50 PM Production of Aromatics with Solvent-Tolerant Pseudomonads - Beyond Titer, Rate and Yield  Nick Wierckx, RWTH Aachen University, Germany
12:50 PM - 2:10 PM Lunch  
2:10 PM - 4:50 PM Session 6: Metabolic Engineering of Higher Eukaryotic Cells
Chair: Diethard Mattanovich, University of Vienna, Austria
 
2:10 PM - 2:50 PM Keynote Presentation: Synthetic Biology-Inspired Treatment Strategies of the Future Martin Fussenegger, ETH Zurich, Switzerland
2:50 PM - 3:15 PM Invited Speaker: Rapid Engineering of Yeast Cell Factories using Iterative Cycles of Design, Build, Test, and Learn on a Genome Scale Huimin Zhao, University of Illinois at Urbana-Champaign, USA
3:15 PM - 3:45 PM Coffee Break  
3:45 PM - 4:10 PM Invited Presentation:  Biologics 4.0: Emergence of the CHO Biofoundry Lars Nielsen, University of Queensland, Australia
4:10 PM - 4:35 PM Invited Presentation: Translational Control of Gene Expression: Leveraging eIF3 for Synthetic Biology  Jamie Cate, University of California, Berkeley, USA
4:35 PM - 4:55 PM Elucidating Amino Acid Metabolism in CHO Cells    Maciek Antoniewicz, University of Delaware, USA
4:55 PM - 6:00 PM Poster Session (Group II) and Reception  
6:00 PM - Evening Dinner Out  

 

Wednesday, June 27, 2018

7:00 AM - 12:00 PM Registration  
8:00 AM - 10:10 AM Session 7: From Lab to Industry – High Value Molecules for Health and Nutrition
Chair: Kirsten Benjamin, Amyris, USA
Chair: Tomohisa Hasunuma, Kobe University, Japan
 
8:00 AM - 8:40 AM Keynote Presentation: Engineering Microorganisms for Production of Isoprenoid Natural Products and Some Not-So-Natural Products Jay Keasling, University of California, Berkeley‎, USA
8:40 AM - 9:05 AM Invited Presentation: Fermented Insect Pheromones for Environmentally Friendly Pest Control Irina Borodina, Technical University of Denmark, Denmark
9:05 AM - 9:30 AM Invited Presentation: Myxobacteria: Biodiversity, Synthetic Biotechnology And Secondary Metabolomics For Natural Product Discovery And Development Rolf Müller, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Germany
9:30 AM - 9:50 AM Industrial-Scale Production of 11 Steviol-Glycosides: from Reb a to Z  Oliver Yu, Conagen Inc., USA
9:50 AM - 10:10 AM The Road to Animal-Free Glycosaminoglycan Production Using Metabolic Engineering of Recombinant Microorganisms   Mattheos Koffas, Rensselaer Polytechnic Institute, USA
10:10 AM - 10:40 AM Coffee Break  
10:40 AM- 12:50 PM Session 8: From Lab to Industry – Big Volume Chemicals, Fuels and Materials
Chair: Michael Lynch, Duke University, USA
Chair: Brian Pfleger, University of Wisconsin-Madison, USA
 
10:40 AM- 11:20 AM Keynote Lecture: Production of Large-Volume Chemicals by Metabolically Engineered Bacteria Sang-Yup Lee, Korea Advanced Institute of Science & Technology, South Korea
11:20 AM- 11:45 AM Invited Presentation: Genome Synthesis and Editing Platforms for Development
of Microbial Cell Factories
Akihiko Kondo, Kobe University and RIKEN Institute, Japan
11:45 AM- 12:10 PM Invited Presentation: Next Generation Industrial Biotechnology Based on Engineering Extremophiles George Chen, Tsinghua University, China
12:10 PM- 12:30 PM Development of an Industrial Process for the Production of Biobased L-Methionine Philippe Soucaille, Toulouse University, France
12:30 PM- 12:50 PM Metabolic Engineering Strategies to Expand the Product Spectrum of Commercial-Scale Gas Fermentation   Michael Köpke, LanzaTech, Inc., USA
12:50 PM - 2:10 PM Lunch  
2:10 PM - 3:50 PM

Session 9A: On the Horizon - Emerging Technologies
Chair: Dina Petranovic, Chalmers University, Sweden

Chair: Christina Smolke, Stanford University, USA

 
2:10 PM - 2:50 PM Keynote Presentation: Perspectives on Metabolic Engineering Greg Stephanopoulos, Massachusetts Institute of Technology, USA
2:50 PM - 3:15 PM Invited Presentation:  Tobias Erb, Max Planck Institute, Germany
3:15 PM - 3:35 PM Optogenetic Control of Engineered Metabolic Pathways  Jose Avalos, Princeton University, USA 
3:35 PM - 3:55 PM Making Biology Easier to Engineer - High Throughput Custom Organism Engineering  Elena Brevnova, Ginkgo Bioworks, USA
3:55 PM - 4:20 PM Coffee Break  
4:20 PM - 5:20 PM Session 9B: On the Horizon - Roadmap to Metabolic Engineering 2035  
5:20 PM - 5:45 PM

Rapid Fire Poster Presentation

Chair: Hal Alper, University of Texas at Austin, USA

 
5:45 PM - 7:30 PM Poster Session (Group II) and Reception  
7:30 PM - 8:30 PM Awards Ceremony  
7:30 PM - 8:00 PM 2018 Jay Bailey Young Investigator Award in Metabolic Engineering   
8:00 PM - 8:30 PM 2018 International Metabolic Engineering Award Presentation:  Metabolic and Evolutionary Engineering of Saccharomyces Cerevisiae for Improved Bioethanol Production Jack Pronk, Delft University of Technology, Netherlands
8:30 PM - 10:00 PM Banquet Dinner  

 

Thursday, June 28, 2018

7:00 AM - 8:00 AM Registration  
8:00 AM - 11:00 AM Parallel Workshop I: Tools for Commercial Bioprocess Design, Economic Analysis, and Scale-up
Chair: Nelson Barton, Genomatica, USA
 
  Keynote Presentation: Developing Commercial Bioprocesses: Best Practices and New Paradigms  Nelson Barton, Genomatica, USA
  Total Solutions Approach: Begin with the End in Mind Michael Japs, Genomatica, USA
9:30 AM - 10:00 AM Coffee Break   
  Optimizing the Balancing Act -- Systematic Approaches to Debottleneck and Develop High Yield and Scalable Strains: Genomatica Butylene Glycol Case Study Harish Nagarajan, Genomatica, USA
  Scaling Down for Better Scaling Up  Jason Crater, Genomatica, USA
  Genomatica 1,4-butanediol Case Study Jason Crater, Genomatica, USA
  Through the Organism’s Eyes: Computational Fluid and Reaction Dynamics for Bioprocesses Design, Operation and Optimization – a Penicillin Case Henk Noorman, DSM Biotechnology Center, USA
  Rapid Pathway Prototyping for Novel Bio-Based Chemicals: Two Case Studies  Massimo Merighi, Ginkgo BioWorks, USA
  Wrap up and Key Takeaways Nelson Barton, Genomatica, USA
8:00 AM - 11:00 AM Parallel Workshop II: Modelling Concepts in Metabolic Engineering
Chair: Costas Maranas, Pennsylvania State University, USA
 
  Keynote Presentation: Quantifying and Shaping Metabolism Costas Maranas, Pennsylvania State University, USA
  Invited Presentation: Web-Based Tools for Metabolic Network Analysis: Thermodynamic Profiling and Enzyme-Cost Minimization Elad Noor, ETH Zurich, Switzerland
9:30 AM - 10:00 AM Coffee Break   
  Invited Presentation: Metabolic Modeling and Computer-Aided Strain Design Using Cobrapy, Cameo, Memote and DD-Decaf Nikolaus Sonnenschein, Technical University of Denmark, Denmark
  Invited Presentation: KBase: An Integrated Systems Biology Knowledgebase for Predictive Biological and Environmental Research Chris Henry, KBase, Argonne National Laboratory, USA
11:00 AM - 11:30 AM IMES General Assembly  
11:30 AM - 12:00 PM Closing remarks  
12:00 PM - 1:00 PM  Lunch   
1:00 PM - 5:00 PM Munich Excursion (optional)