CEP: May 2018

Even though translational medicine has been defined in different ways, the central theme is using a multidisciplinary approach to translate novel scientific and technological findings from bench to bedside to address human health in an affordable manner. Read the 6 articles in this month's special section to learn more. Other topics in this issue include improving evaporation efficiency and impellers for Laminar-Flow Mixing

Editorial

Print Is Not Dead

Discussion Central, AIChE’s online community for professional members, recently dealt with the question “Is print dead?” — a topic that is near and dear to me. It is a question we in the publishing business wrestle with continually...

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Consider Hydrofoil Impellers for Laminar-Flow Mixing

May
2018
Fluids and Solids Handling
Gregory Benz
Hydrofoil impellers are typically associated with turbulent-flow mixing. Simple calculations, computational fluid dynamics, mixing software, and laboratory testing reveal that they are also effective in laminar-flow applications.

Engineering the Precise Translation of Novel Medicines

May
2018
SBE Special Section
The field of bioengineering has placed engineers at the frontier of human health. In fact, medical schools at Univ. of Illinois Urbana-Champaign, Texas A&M, and other universities are developing programs with an “engineering-centric medicine” approach.

Designing Drug Delivery Systems for Articular Joints

May
2018
SBE Special Section
Brett C. Geiger, Alan J. Grodzinsky, Paula Hammond
No disease-modifying drug exists for osteoarthritis due to poor drug delivery within joints. Engineered biomaterials could address this challenge by improving the duration and targeting of therapies.

Curtailing Antibiotic Use in Livestock Production

May
2018
SBE Special Section
Yiannis N. Kaznessis
For decades, livestock producers have routinely administered antibiotics to animals to make them grow faster or as a preventive treatment against disease. This may be contributing to the increasing number of humans being infected by antibiotic-resistant bacteria. Researchers are now searching for viable alternatives.

Recent Advances in Hydrogels for Tissue Engineering

May
2018
SBE Special Section
Samad Ahadian, Houman Savoji, Ali Khademhosseini
Hydrogels could play an important role in the fabrication of functional tissues for regenerative medicine. This article describes the developments in polymer chemistry, nanomaterials, molecular biology, and microscale technologies that are spurring advances in hydrogel fabrication.

Going Small Is Big: Creating Organoids for Regenerative Medicine

May
2018
SBE Special Section
Ogechi Ogoke, Mitchell H. Maloy, Saber Meamardoost, Natesh Parashurama
Organoids are a promising tool to replicate key structural and functional features of human organs. Recent developments in organoids to model the liver, biliary tract, and pancreas have the potential to advance regenerative medicine.

Direct Production of Engineered Cardiac Tissue within Hybrid Biomaterials

May
2018
SBE Special Section
Morgan Ellis, Elizabeth Lipke
The human heart contains highly specialized cells that are especially vulnerable to damage because they lack regenerative capabilities. This article describes a novel method for encapsulating and directly differentiating induced pluripotent stem cells in hybrid biomaterials to form cardiac tissue.

SBE Special Section: Translational Medicine (Complete 44-Page Section)

May
2018
SBE Special Section
Engineering the Precise Translation of Novel Medicines; From Data to Diagnosis: The Search for Biochemical Markers of Autism Spectrum Disorder; Designing Drug Delivery Systems for Articular Joints; Curtailing Antiobiotic Use in Livestock Production; Recent Advances in Hydrogels for Tissue Engineering; Going Small is Big: Creating Organoids for Regenerative Medicine; Direct Production of Engineered Cardiac Tissue within Hybrid Biomaterials
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