Share Stem cell engineering is a distinct field at the intersection of stem cell biology, engineering and regenerative medicine. The understanding of how biophysical and biochemical cues in the cells’ surrounding regulate cell fate and differentiation can be harnessed for the development of novel approaches to modulate stem cell behaviors and leading eventually to their clinical utilization. As stem cell knowledge matures, its appropriate translation to the clinical setting is crucial for success. Thus, in addition to fundamental studies, approaches to monitor stem cell responses, enhance regeneration through material properties, uncover the immunological response during regeneration and the accurate design of clinical trials are all required to unlock the therapeutic potential of stem cells. Technical Program Press Coverage Chari Sheila, Cell Press & Elsevier Sessions: In situ/endogenous regeneration Differentiation & Morphogenesis I Differentiation & Morphogenesis II Microtechnologies & High Throughput Screening/Disease models Computational Stem Cell Biology Immune engineering Clinical applications and challenges Towards regenerative therapies Chairs: Karen Christman, University of California San Diego, USA Sharon Gerecht, Johns Hopkins University, USA Plenary Speakers: David Mooney, Harvard University Molly Shoichet, University of Toronto Keynote Speakers: Christopher Breuer, Nationwide Children's Hospital Gordana Vunjak-Novakovic, Columbia University Jennifer Elisseeff, Johns Hopkins University Matthias Lutolf, Ecole Polytechnique Federale de Lausanne Michael Laflamme, University of Toronto Peter Zandstra, University of Toronto Todd McDevitt, Gladstone Institute Jeff Bulte, Johns Hopkins University Confirmed Speakers Ben Cosgrove, Cornell University Hai-Quan Mao, Johns Hopkins University Jae-Won Shin, The University of Illinois at Chicago Joaquim Cabral, Instituto Superior Técnico Kevin D'amour, Viacyte Inc. Milica Radisic, University of Toronto Nicolas Elvassore, BioERA Prashant Mali, University of California, San Diego Randy Ashton, University of Wisconsin–Madison Sean Palecek, University of Wisconsin-Madison Song Li, University of California, Los Angeles Thomas Gilbert, Acell Warren Grayson, Johns Hopkins University Featured Speakers Christopher Breuer Christopher Breuer, M.D. is a Professor of Surgery at The Ohio State University. He serves as the Director of the Tissue Engineering Program and as Director of Surgical Research at Nationwide Children’s Hospital. Dr Breuer is a Board certified Pediatric surgeon. He is a staff surgeon and member of the Division of Pediatric Surgery at Nationwide Children’s Hospital. Dr. Breuer runs a NIH funded laboratory that focuses on cardiovascular tissue engineering. His work is both basic and applied in nature. His basic science research is centered on investigating the cellular and molecular...Read more Jeff Bulte The clinical development of novel immune and stem cell therapies calls for suitable methods that can follow the fate of cells non-invasively in humans at high resolution. The Bulte Lab has pioneered methods to label cells magnetically (using tiny superparamagnetic iron oxide nanoparticles) in order to make them visible by MR imaging. While the lab is doing basic bench-type research, there is a strong interaction with the clinical interventional radiology and oncology groups in order to bring the methodologies into the clinicRead more Jennifer Elisseeff Professor and Director, Translational Tissue Engineering Center Wilmer Eye Institute and Departments of Biomedical Engineering, Orthopedic Surgery, Chemical and Biological Engineering, and Materials Science and Engineering Dr. Elisseeff is a Professor and Director of the Translational Tissue Engineering Center at Johns Hopkins Department of Biomedical Engineering and the Wilmer Eye Institute with appointments in Chemical and Biological Engineering, Materials Science and Orthopedic Surgery. She was elected a Fellow of the American Institute of Medical and Biological...Read more Michael Laflamme My laboratory is broadly interested in the use of stem cells for cardiac repair, but with a particular emphasis on the preclinical development of cardiac therapies based on human pluripotent stem cells (hPSCs). Much of our recent work has focused on understanding and improving the electrophysiological properties of hPSC-derived cardiomyocytes, as the electrical immaturity and automaticity of these cells represents a significant barrier to their successful translation. We have ongoing research efforts aimed at 1) deriving specialized cardiac subtypes from hPSCs, 2) promoting the structural...Read more Matthias Lutolf Institute of Bioengineering, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland Professor Matthias Lutolf is the director of the Institute of Bioengineering and head of the Laboratory of Stem Cell Bioengineering at EFP Lausanne. He was trained as a Materials Engineer at ETH Zurich where he also carried out his Ph.D. studies on the development of a novel class of biomaterials for tissue engineering (awarded with the ETH medal). Lutolf carried out postdoctoral studies at the Baxter Laboratory in Stem Cell...Read more Todd McDevitt The McDevitt lab is focused on the engineering of innovative technologies to translate the morphogenic potential of stem cells as models of development and disease, as well to develop cellular and molecular therapies aimed to treat degenerative diseases and traumatic injuries. Since stem cells are promising for a number of applications, the emphasis of the McDevitt Lab is on the development of technology platforms to advance therapies that span multiple diseases. Our technologies are applicable to a wide variety of diseases, including cardiovascular, orthopedic and neurological disorders....Read more David Mooney David Mooney is the Pinkas Family Professor of Bioengineering in the Harvard School of Engineering and Applied Sciences, and a Core Faculty Member of the Wyss Institute. His laboratory designs biomaterials to make cell and protein therapies effective and practical approaches to treat disease. His team created the first biomaterial-based, therapeutic cancer vaccine, currently in a clinical trial for melanoma. He is a member of the National Academy of Engineering, and the National Academy of Medicine. He has won numerous awards, including the Clemson Award from the SFB, MERIT award from...Read more Molly Shoichet Dr. Molly Shoichet holds the Tier 1 Canada Research Chair in Tissue Engineering and is University Professor of Chemical Engineering & Applied Chemistry, Chemistry and Biomaterials & Biomedical Engineering at the University of Toronto. She is an expert in the study of Polymers for Drug Delivery & Regeneration which are materials that promote healing in the body. Dr. Shoichet has published over to 480 papers, patents and abstracts and has given over 310 lectures worldwide. She currently leads a laboratory of 25 researchers and has graduated 134 researchers over the past...Read more Gordana Vunjak-Novakovic Gordana Vunjak-Novakovic is a Serbian American biomedical engineer. She is the Mikati Foundation Professor of Biomedical Engineering and Professor of Medical Sciences at Columbia University, where she directs the Laboratory for Stem Cells and Tissue Engineering. Her lab focuses on engineering human tissues for regenerative medicine, stem cell research and modeling of disease. She has published over 335 journal articles, 58 book chapters and three books on tissue engineering. According to Google Scholar, her papers have been cited over 29,600 times, and she has an h-index of 97 as of March...Read more Proceedings Proceedings of the 5th International Conference on StemCell Engineering are now available: Browse proceedings for this conference
Christopher Breuer Christopher Breuer, M.D. is a Professor of Surgery at The Ohio State University. He serves as the Director of the Tissue Engineering Program and as Director of Surgical Research at Nationwide Children’s Hospital. Dr Breuer is a Board certified Pediatric surgeon. He is a staff surgeon and member of the Division of Pediatric Surgery at Nationwide Children’s Hospital. Dr. Breuer runs a NIH funded laboratory that focuses on cardiovascular tissue engineering. His work is both basic and applied in nature. His basic science research is centered on investigating the cellular and molecular...Read more
Jeff Bulte The clinical development of novel immune and stem cell therapies calls for suitable methods that can follow the fate of cells non-invasively in humans at high resolution. The Bulte Lab has pioneered methods to label cells magnetically (using tiny superparamagnetic iron oxide nanoparticles) in order to make them visible by MR imaging. While the lab is doing basic bench-type research, there is a strong interaction with the clinical interventional radiology and oncology groups in order to bring the methodologies into the clinicRead more
Jennifer Elisseeff Professor and Director, Translational Tissue Engineering Center Wilmer Eye Institute and Departments of Biomedical Engineering, Orthopedic Surgery, Chemical and Biological Engineering, and Materials Science and Engineering Dr. Elisseeff is a Professor and Director of the Translational Tissue Engineering Center at Johns Hopkins Department of Biomedical Engineering and the Wilmer Eye Institute with appointments in Chemical and Biological Engineering, Materials Science and Orthopedic Surgery. She was elected a Fellow of the American Institute of Medical and Biological...Read more
Michael Laflamme My laboratory is broadly interested in the use of stem cells for cardiac repair, but with a particular emphasis on the preclinical development of cardiac therapies based on human pluripotent stem cells (hPSCs). Much of our recent work has focused on understanding and improving the electrophysiological properties of hPSC-derived cardiomyocytes, as the electrical immaturity and automaticity of these cells represents a significant barrier to their successful translation. We have ongoing research efforts aimed at 1) deriving specialized cardiac subtypes from hPSCs, 2) promoting the structural...Read more
Matthias Lutolf Institute of Bioengineering, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland Professor Matthias Lutolf is the director of the Institute of Bioengineering and head of the Laboratory of Stem Cell Bioengineering at EFP Lausanne. He was trained as a Materials Engineer at ETH Zurich where he also carried out his Ph.D. studies on the development of a novel class of biomaterials for tissue engineering (awarded with the ETH medal). Lutolf carried out postdoctoral studies at the Baxter Laboratory in Stem Cell...Read more
Todd McDevitt The McDevitt lab is focused on the engineering of innovative technologies to translate the morphogenic potential of stem cells as models of development and disease, as well to develop cellular and molecular therapies aimed to treat degenerative diseases and traumatic injuries. Since stem cells are promising for a number of applications, the emphasis of the McDevitt Lab is on the development of technology platforms to advance therapies that span multiple diseases. Our technologies are applicable to a wide variety of diseases, including cardiovascular, orthopedic and neurological disorders....Read more
David Mooney David Mooney is the Pinkas Family Professor of Bioengineering in the Harvard School of Engineering and Applied Sciences, and a Core Faculty Member of the Wyss Institute. His laboratory designs biomaterials to make cell and protein therapies effective and practical approaches to treat disease. His team created the first biomaterial-based, therapeutic cancer vaccine, currently in a clinical trial for melanoma. He is a member of the National Academy of Engineering, and the National Academy of Medicine. He has won numerous awards, including the Clemson Award from the SFB, MERIT award from...Read more
Molly Shoichet Dr. Molly Shoichet holds the Tier 1 Canada Research Chair in Tissue Engineering and is University Professor of Chemical Engineering & Applied Chemistry, Chemistry and Biomaterials & Biomedical Engineering at the University of Toronto. She is an expert in the study of Polymers for Drug Delivery & Regeneration which are materials that promote healing in the body. Dr. Shoichet has published over to 480 papers, patents and abstracts and has given over 310 lectures worldwide. She currently leads a laboratory of 25 researchers and has graduated 134 researchers over the past...Read more
Gordana Vunjak-Novakovic Gordana Vunjak-Novakovic is a Serbian American biomedical engineer. She is the Mikati Foundation Professor of Biomedical Engineering and Professor of Medical Sciences at Columbia University, where she directs the Laboratory for Stem Cells and Tissue Engineering. Her lab focuses on engineering human tissues for regenerative medicine, stem cell research and modeling of disease. She has published over 335 journal articles, 58 book chapters and three books on tissue engineering. According to Google Scholar, her papers have been cited over 29,600 times, and she has an h-index of 97 as of March...Read more