EpiBio 2019 Technical Program


Thursday, September 12

7:30 AM - 12:00 PM Registration
9:00 AM - 9:45 AM Keynote Speaker: Epigenetic mechanisms governing cell differentiation and cancer processes

Luciano Di Croce
9:45 AM - 12:00 PM Session 1A: Writing Epigenetic Modifications (Chair: M. G. Rots)
9:45 AM - 10:15 AM Invited Speaker: Chemically Activating Chromatin

Nate Hathaway
10:15 AM - 10:30 AM Selected Speaker: Deciphering the Histone Acetyl Code in Human Cells with dCas9-Based Epigenome Editing

Isaac Hilton
10:30 AM - 11:00 AM Coffee Break
11:00 AM - 11:15 AM Selected Speaker: CRISPR-Based Targeted Epigenetic Editing Enables Glyco-Engineering in Chinese Hamster Ovary (CHO) Cells

Nicolas Marx
11:15 AM - 12:00 PM Keynote Speaker: Epigenome Editing to Program Cell Fate Decisions

Charles Gersbach
12:00 PM - 2:00 PM Lunch Break
2:00 PM - 5:00 PM Session 1B: Writing Epigenetic Modifications (Chair: K.A. Haynes)
2:00 PM - 2:30 PM Invited Speaker: DNA Methylation and Oxidation in Developmental Control

Guoliang Xu
2:30PM - 3:00 PM Invited Speaker: Setting of DNA methylation - from molecular mechanisms to epigenome dynamics

Albert Jeltsch
3:00 PM - 3:30 PM Coffee Break
3:30 PM - 3:45 PM Selected Speaker: Epigenome Editing of Alternatively Spliced Exons Relevant for the EMT Is Sufficient to Change Splicing Outcome

Alexandre Segelle
3:45 PM - 4:00 PM Selected Speaker: Highly Effective Epigenome Editing and Gene Regulation By the Customizable dCas9-Sssavi Combinatorial Recruitment Platform

Tessa Swain
4:00 PM - 4:15 PM Selected Speaker: Identification of Flavin Mononucleotide As Cell-Active Artificial N6-Methyladenosine RNA Demethylase

Liang Cheng
4:15 PM - 5:30 PM Poster Session (list of posters here)

Friday, September 13

7:30 AM - 12:00 PM Registration
9:00 AM - 12:00 PM Session 2: Sensing and detection of epigenetic modifications (Chair: A. Jeltsch)
9:00 AM - 9:30 AM Invited Speaker: Nucleosomal Asymmetry Shapes Histone Mark Binding at Bivalent Domains

Philipp Voigt
9:30 AM - 10:00 AM Invited Speaker: Mitochondrial epigenetic editing/ Mitochondrial DNA methylation: is it or is it not?

Marianne G Rots
10:00 AM -10:15 AM  Selected Speaker: Synthetic Heterochromatin Domain Formation Via CRISPR/dCas9

Yuchen Gao
10:15 AM -10:30 AM  Selected Speaker: Modification-Specific Intracellular Antibodies for Monitoring Histone Modification and Transcription In Vivo

Hiroshi Kimura
10:30 AM - 11:00 AM Coffee Break
11:00 AM -11:15 AM  Selected Speaker: Precise DNA Epigenome Profiling: High-Resolution Economical Approaches for Detection of Genomic Cytosine Modifications

Edita Kriukiene
11:15 AM -11:30 AM  Selected Speaker: Engineered Chromatin Readers Reveal the Genome-Wide Proteome Composition at Key Chromatin States in Living Cells

Rodrigo Villasenor
11:30 AM -11:45 AM  Selected Speaker:Development of a Computational Tool for the Analysis of Bisulfite-Free DNA Sequencing Data

Gergana Velikova
11:45 AM - 2:00 PM Lunch on your own
2:00 PM - 4:30 PM Session 3: Single cell Epigenetics (Chair: L Bintu)
2:00 PM - 2:30 PM Invited Speaker: Human cerebral organoids model disease-relevant gene expression dynamics

Albert Keung
2:30 PM - 3:00 PM Invited Speaker: Aging alters the epigenetic asymmetry of HSC division

Carolina Florian
3:00 PM - 3:30 PM Coffee Break
3:30 PM - 4:00 PM Invited Speaker: Dynamic epigenetic regulation: Single cells can make a difference

Pernette Verschure
4:00 PM - 4:15 PM Selected Speaker: Regulation of Chromatin State in 3D Tissues

H. Courtney Hodges
4:15 PM - 4:30 PM Selected Speaker: Integrative Single-Cell Chromatin and Transcriptome Profiling Uncovers Cell-Type Specific Regulatory Interactions

Sai Ma

Saturday, September 14

7:30 AM - 12:00 PM Registration
9:00 AM - 9:45 AM Keynote Speaker: Changing Your Mind: Targeted Epigenetic Editing in the Brain

Dave Segal
9:45 AM - 10:30 PM Session 4: Clinical Epigenetics (Chair: PJ Verschure)
9:45 AM - 10:15 AM Invited Speaker: Epigenetic control of fibroblast activation

Michael Zeisberg
10:15 AM - 10:45 AM Selected Speaker: Chemosensitivity Associated Chromatin Conformation Changes Influence DNA Damage Distribution in Ovarian Cancer Cells

Robert Brown
10:45 AM - 11:15 AM Coffee Break
11:15 AM - 11:45 AM Invited Speaker: Epigenetic engineering in the cancer microenvironment: from editing drivers to targeted delivery systems

Pilar Blancafort
11:45 AM - 12:30 PM Keynote Speaker:  Chemical Targeting of DNA and histone methylation to reprogram cells in human diseases: challenges and future perspectives

Paola Arimodo
12:30 PM - 12:45 PM Closing Remarks