Share Thursday, September 12 7:30 AM - 12:00 PM Registration 9:00 AM - 9:45 AM Keynote Speaker: Epigenetic mechanisms governing cell differentiation and cancer processes Luciano Di Croce 9:45 AM - 12:00 PM Session 1A: Writing Epigenetic Modifications (Chair: M. G. Rots) 9:45 AM - 10:15 AM Invited Speaker: Chemically Activating Chromatin Nate Hathaway 10:15 AM - 10:30 AM Selected Speaker: Deciphering the Histone Acetyl Code in Human Cells with dCas9-Based Epigenome Editing Isaac Hilton 10:30 AM - 11:00 AM Coffee Break 11:00 AM - 11:15 AM Selected Speaker: CRISPR-Based Targeted Epigenetic Editing Enables Glyco-Engineering in Chinese Hamster Ovary (CHO) Cells Nicolas Marx 11:15 AM - 12:00 PM Keynote Speaker: Epigenome Editing to Program Cell Fate Decisions Charles Gersbach 12:00 PM - 2:00 PM Lunch Break 2:00 PM - 5:00 PM Session 1B: Writing Epigenetic Modifications (Chair: K.A. Haynes) 2:00 PM - 2:30 PM Invited Speaker: DNA Methylation and Oxidation in Developmental Control Guoliang Xu 2:30PM - 3:00 PM Invited Speaker: Setting of DNA methylation - from molecular mechanisms to epigenome dynamics Albert Jeltsch 3:00 PM - 3:30 PM Coffee Break 3:30 PM - 3:45 PM Selected Speaker: Epigenome Editing of Alternatively Spliced Exons Relevant for the EMT Is Sufficient to Change Splicing Outcome Alexandre Segelle 3:45 PM - 4:00 PM Selected Speaker: Highly Effective Epigenome Editing and Gene Regulation By the Customizable dCas9-Sssavi Combinatorial Recruitment Platform Tessa Swain 4:00 PM - 4:15 PM Selected Speaker: Identification of Flavin Mononucleotide As Cell-Active Artificial N6-Methyladenosine RNA Demethylase Liang Cheng 4:15 PM - 5:30 PM Poster Session (list of posters here) Friday, September 13 7:30 AM - 12:00 PM Registration 9:00 AM - 12:00 PM Session 2: Sensing and detection of epigenetic modifications (Chair: A. Jeltsch) 9:00 AM - 9:30 AM Invited Speaker: Nucleosomal Asymmetry Shapes Histone Mark Binding at Bivalent Domains Philipp Voigt 9:30 AM - 10:00 AM Invited Speaker: Mitochondrial epigenetic editing/ Mitochondrial DNA methylation: is it or is it not? Marianne G Rots 10:00 AM -10:15 AM Selected Speaker: Synthetic Heterochromatin Domain Formation Via CRISPR/dCas9 Yuchen Gao 10:15 AM -10:30 AM Selected Speaker: Modification-Specific Intracellular Antibodies for Monitoring Histone Modification and Transcription In Vivo Hiroshi Kimura 10:30 AM - 11:00 AM Coffee Break 11:00 AM -11:15 AM Selected Speaker: Precise DNA Epigenome Profiling: High-Resolution Economical Approaches for Detection of Genomic Cytosine Modifications Edita Kriukiene 11:15 AM -11:30 AM Selected Speaker: Engineered Chromatin Readers Reveal the Genome-Wide Proteome Composition at Key Chromatin States in Living Cells Rodrigo Villasenor 11:30 AM -11:45 AM Selected Speaker:Development of a Computational Tool for the Analysis of Bisulfite-Free DNA Sequencing Data Gergana Velikova 11:45 AM - 2:00 PM Lunch on your own 2:00 PM - 4:30 PM Session 3: Single cell Epigenetics (Chair: L Bintu) 2:00 PM - 2:30 PM Invited Speaker: Human cerebral organoids model disease-relevant gene expression dynamics Albert Keung 2:30 PM - 3:00 PM Invited Speaker: Aging alters the epigenetic asymmetry of HSC division Carolina Florian 3:00 PM - 3:30 PM Coffee Break 3:30 PM - 4:00 PM Invited Speaker: Dynamic epigenetic regulation: Single cells can make a difference Pernette Verschure 4:00 PM - 4:15 PM Selected Speaker: Regulation of Chromatin State in 3D Tissues H. Courtney Hodges 4:15 PM - 4:30 PM Selected Speaker: Integrative Single-Cell Chromatin and Transcriptome Profiling Uncovers Cell-Type Specific Regulatory Interactions Sai Ma Saturday, September 14 7:30 AM - 12:00 PM Registration 9:00 AM - 9:45 AM Keynote Speaker: Changing Your Mind: Targeted Epigenetic Editing in the Brain Dave Segal 9:45 AM - 10:30 PM Session 4: Clinical Epigenetics (Chair: PJ Verschure) 9:45 AM - 10:15 AM Invited Speaker: Epigenetic control of fibroblast activation Michael Zeisberg 10:15 AM - 10:45 AM Selected Speaker: Chemosensitivity Associated Chromatin Conformation Changes Influence DNA Damage Distribution in Ovarian Cancer Cells Robert Brown 10:45 AM - 11:15 AM Coffee Break 11:15 AM - 11:45 AM Invited Speaker: Epigenetic engineering in the cancer microenvironment: from editing drivers to targeted delivery systems Pilar Blancafort 11:45 AM - 12:30 PM Keynote Speaker: Chemical Targeting of DNA and histone methylation to reprogram cells in human diseases: challenges and future perspectives Paola Arimodo 12:30 PM - 12:45 PM Closing Remarks