Pernette Verschure

Pernette Verschure

Associate Professor
University of Amsterdam

Pernette J. Verschure obtained her PhD at the University Hospital Nijmegen, the Netherlands in 1995 and continued as junior researcher at Smith Kline Beecham Pharmaceuticals, Philadelphia, USA. She started in 1997 to study genome organization and received personal career fellowships from the Dutch Organization for Scientific Research and the Netherlands Royal Netherlands Academy of Arts and Sciences. She was visiting scientist in the lab of prof. Andrew Belmont, Department of Cell and Structural Biology, University of Illinois, USA. She received several awards for her work on functional chromosome organization (in 2006 the Feulgen Prize from the Society for Histochemistry). In 2013 she was appointed associate professor at the Swammerdam Institute for Life Sciences, University of Amsterdam, the Netherlands and with her group she focuses on spatial and temporal control of epigenetic regulation in mammalian cells and the contribution of epigenetic plasticity and transcriptional cell-to-cell variability to altered cell behaviour in (i) breast cancer endocrine therapy resistance development, (ii) UV-induced damage and repair regulation and (iii) epigenetic-based age determination as forensic application. She participated in EU-funded research projects (BIO-MED, D-GENOME). She initiated and coordinated 'EpiPredict' EU H2020 Marie Slodowska-Curie Innovative Training Network (http://www.epipredict.eu/) focusing on epigenetic regulation of breast cancer progression. She is Workgroup leader and member of the management team of the COST (CA18127) International Nucleome Consortium (https://www.cost.eu/actions/CA18127/). She collaborates with the Netherlands Forensic Institute and is coordinator of the Co van Ledden Hulschebosch forensic research and expertise center. She is (and has been) on various scientific advisory boards (SYNENERGENE https://www.synenergene.eu/, CASyM/SysMedIBD, https://www.casym.eu/eu-projects, MESI-STRAT https://mesi-strat.eu/, BREAST-PREDICT http://www.breastpredict.com/, EMBL/EMBC Contact committee advising EMBO/EMBL). She is Associate Editor of the Journal of Histochemistry and Cytochemistry, Review Editor of Frontiers in Bioengineering and Biotechnology and member of the Dutch academic work group of the Origins Center virtual institute (https://www.origins-center.nl/) an initiative of the Dutch National Science Agenda.

Selected publications

1. Beckman W, Vuist IM, Kempe H, Verschure PJ (2018): Cell-to-Cell Transcription Variability as Measured by Single-Molecule RNA FISH to Detect Epigenetic State Switching. Methods Mol Biol. 1767:385.

2. Magnani L, Frigè G, Gadaleta RM, Corleone G, Fabris S, Kempe H, Verschure PJ, Barozzi I, Vircillo V, Hong SP, Perone Y, Saini M, Trumpp A, Viale G, Neri A, Ali S, Colleoni MA, Pruneri G, Minucci S. (2017): Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ERα metastatic breast cancer Nat Genet 49:444.

3. Naue J, Hoefsloot HCJ, Mook ORF, Rijlaarsdam-Hoekstra L, van der Zwalm MCH, Henneman P, Kloosterman AD, Verschure PJ.(2017): Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression. Forensic Sci Int Genet. 31:19.

4. Wijchers PJ, Krijger PH, Geeven D, Zhu Y, Denker A, Verstegen MJ, Valdes-Queszada C, Vermeulen C, Janssen M, Teunissen H, Anink-Groenen LC, Verschure PJ, de Laat W. (2016): Cause and consequence of tethering a subTAD to different nuclear compartments. Mol Cell 61: 461.

5. Kempe H, Schwabe A, Cremazy F, Verschure PJ, Bruggeman FJ  (2015): The volumes and transcript counts of single cells reveal