Amy Wagers | AIChE

Amy Wagers

Professor
Harvard Medical School

Work in the Wagers Lab focuses on understanding the mechanisms that regulate the function of blood-forming and muscle-forming stem cells so that their potential can be optimally exploited for the treatment of diseases such as cancer, anemia, muscular dystrophy, and diabetes. A major goal of our research has been to identify mechanisms that control the migration and expansion of blood-forming stem cells, with the aim of improving patient outcomes in bone marrow transplant. Our current work suggests that both intrinsic and extrinsic factors cooperate to determine stem cell fate, and we have recently identified particular gene regulators that appear to coordinate stem cell migration and expansion. This new knowledge suggests novel approaches to modulate stem cell activity and ultimately may lead to more effective strategies for bone marrow transplantation.