AIChE Journal Highlight: Non-Viral Gene Delivery for Cancer Therapy

May
,
2017

As researchers gain more insight into the molecular basis of cancer cell genesis, proliferation, and metastasis, gene therapy has emerged as a promising strategy for cancer treatment. In particular, the non-viral delivery of therapeutic nucleic acid cargo using polymeric nanoparticles can be a safer and more effective way to treat diseases such as brain cancer, say Yuan Rui, Gabriella QuiÑones, and Jordan Green of Johns Hopkins Univ. in the May AIChE Journal Perspective article, “Biodegradable and Bioreducible Poly(Beta-Amino Ester) Nanoparticles for Intracellular Delivery to Treat Brain Cancer.”

In their article, the authors discuss the challenges to successful gene delivery and strategies to overcome them using polymeric nanoparticles, with an emphasis on the treatment of glioblastoma multiforme (GBM). GBM is an extremely deadly form of brain cancer that claims the lives of 15,000 Americans each year. Median survival after surgery and chemotherapy is less than two years.

Gene therapy, in which exogenous nucleic acids are introduced into the cell to alter gene expression, is a promising way to treat GBM, because it could selectively kill off cancer cells while leaving healthy tissue...

Would you like to access the complete CEP Article?

No problem. You just have to complete the following steps.

You have completed 0 of 2 steps.

  1. Log in

    You must be logged in to view this content. Log in now.

  2. AIChE Membership

    You must be an AIChE member to view this article. Join now.

Copyright Permissions: 

Would you like to reuse content from CEP Magazine? It’s easy to request permission to reuse content. Simply click here to connect instantly to licensing services, where you can choose from a list of options regarding how you would like to reuse the desired content and complete the transaction.