AIChE Journal Highlight: Optimizing End-to-End Pharmaceutical Manufacturing Processes | AIChE

You are here

AIChE Journal Highlight: Optimizing End-to-End Pharmaceutical Manufacturing Processes

Journal Highlight

September AIChE Journal

Manufacturing an active pharmaceutical ingredient (API) involves a sequence of chemical and physical transformations, with different ways to execute each step. In the pharmaceutical industry, the traditional approach is to perform each operation batchwise, where each step is completed separately, and the next step waits for the preceding one to finish. The counterpart to batchwise operation is the continuous operating mode, where material flows continuously from one operation to the next. Combining both modes gives rise to a hybrid manufacturing process.

Continuous manufacturing offers several advantages that have prompted the industry to explore it over the past decades. These benefits include the use of smaller equipment, reduced in-process material storage, limited exposure to hazardous materials, and more consistent product quality. However, continuous processes have a downside: they require an initial startup period before achieving steady operation and on-specification products. During this startup phase, materials and time are consumed, and off-spec products must be discarded before nominal operation is achieved. This startup time, which depends on the process dynamics, becomes a critical...

Would you like to access the complete CEP Article?

No problem. You just have to complete the following steps.

You have completed 0 of 2 steps.

  1. Log in

    You must be logged in to view this content. Log in now.

  2. AIChE Membership

    You must be an AIChE member to view this article. Join now.

Copyright Permissions 

Would you like to reuse content from CEP Magazine? It’s easy to request permission to reuse content. Simply click here to connect instantly to licensing services, where you can choose from a list of options regarding how you would like to reuse the desired content and complete the transaction.