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Conference Presentations - 2012 AIChE Annual Meeting

A Novel QbD Tool for Statistical Data Analysis

Oct 30, 2012
Linas Mockus
One of cornerstones of Quality by Design (QbD) is Design of Experiments (DoE). However, in addition to DoE, ICH Q8 (R2) recommends an enhanced approach to product and process development which is based on mechanistic first principle models. Such predictive models require parameters such as kinetic...

NETL CO2 Injection and Storage Cost Model

Oct 30, 2012
Tim Grant
The U.S. Department of Energy’s National Energy Technology Laboratory (NETL) has developed a model to estimate the costs of storing captured CO 2 . This model includes the range of costs from initial regional geologic evaluation through site characterization, permitting, injection/MVA operations,...

Variable Selection in Multivariate Modeling of Drug Product Formula and Process

Oct 30, 2012
Yong Cui
Multivariate data analysis methods such as partial least square (PLS) modeling have been increasingly applied to product development, particularly in the quality-by design paradigm. This study applied the PLS modeling to analyze a product development dataset combining a design of experiment study...

Vision-Based Solar Irradiation Prediction for the Control of Solar-Thermal Reactors

Oct 30, 2012
Elizabeth Saade Saade
One of the biggest challenges that solar thermochemical processes face is dealing with the intermittent nature of solar irradiation. Changes in solar irradiation directly affect the performance of solar-thermal reactors causing unnecessary shutdowns and start-ups, complications in the purification...

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