(84c) Scale up of Dry Granulation from Pilot Scale to Commercial Manufacturing
World Congress on Particle Technology
Wednesday, April 25, 2018 - 8:59am to 9:21am
A case study is presented outlining the techniques used to transfer a roller compaction process from an Alexanderwerk WP120 in the development labs to a WP200 in a commercial manufacturing environment. Additionally techniques will be discussed which look at transferring from an Alexanderwerk to a Gerteis unit and subsequently scaling from a Gerteis Mini-Pactor to a Macro-Pactor. Ribbon density and particle size distribution of the granulation along with dissolution of the tablets produced were the primary outputs used to determine whether material manufactured on any unit was equivalent and/or appropriate.