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Contact: McMullin, Hugh (

Upstream Process Development Scientist

Upstream Process Development Scientist

At Codexis, we are creating sustainable chemicals, pharmaceutical processes, and renewable ingredients that make industry more efficient, productive and profitable. Industrial biotechnology from Codexis reengineers enzymes and microorganisms – nature’s catalysts – and puts them to work to solve real global challenges for the world’s largest companies.

Position Description:  

The Upstream Process Development Scientist will be responsible for the development of recombinant protein production processes and to successfully oversee the transfer of these processes to contract manufacturers. The ideal candidate will have experience with the optimization of enzyme production in microbial expression systems. This position offers the opportunity to work in a multidisciplinary team in a challenging and dynamic environment.


The Process Development Scientist will be responsible for:

  • Development of fermentation and downstream recovery processes for recombinant proteins including enzymes expressed in microbial hosts.
  • Development of fermentation processes using scale down models to predict process performance at manufacturing scale.
  • Development of unit operations at the bench and pilot-scale (10-500L) such as, centrifugation homogenization, micro filtration, ultra filtration and depth filtration.
  • Leading process development, optimization, characterization, scale-up and tech transfer to contract manufacturing.
  • Providing troubleshooting support to commercial manufacturing operations.
  • Participating in strain, process, and cost efficiency improvement efforts.
  • Must be able to lead multidisciplinary team, design project experiments and overall direction, and be able to communicate results and challenges to key stakeholders.
  • Demonstrated supervisory experience.
  • Meeting timelines for multiple projects that may be at different stages of development.
  • Identifying and evaluating new technologies for fermentation and recovery processes.
  • Authoring equipment and process SOPs and Process Safety Reviews.

Critical Competencies:

  • Strong knowledge of microbial systems, physiology and cellular metabolism, coupled with practical knowledge of process engineering and plant operations
  • Strong technical background and direct hands-on experience with fermentation processes and downstream processing unit operations such as , centrifugation, homogenization, ultra filtration, sterile filtration, lyophilization etc.
  • Sound understanding of basic protein biochemistry, microbiology, and recombinant protein expression in microbial hosts.
  • Experience in enzyme activity, protein characterization, and protein determination.
  • Experimental design and data analysis capabilities including Design of Experiments (DOE).
  • Understanding of engineering issues involved in scale up and possesses both practical and analytical skills to implement relevant scale down models.
  • Experience with lyophilization is a plus.
  • Ability to prioritize responsibilities, multi-task and remain flexible with changing needs.
  • Must be motivated and able to work under tight deadlines.
  • Excellent interpersonal and communication (oral and written) skills, documentation, organization, good record keeping, writing reports and SOPs.
  • Able to work effectively in cross functional teams to solve manufacturing problems or implement improved procedures.
  • Mentor and supervise staff as well as work effectively with management teams. 
  • Some travel to  manufacturing sites will be required


Ph.D. in Chemical Engineering, Microbiology, Microbial Physiology, or related discipline with 3-5 years of relevant industrial experience; or B.S. with at least 10 years relevant industrial experience.

The position comes with a competitive compensation and benefits package, including paid company holidays, paid time off, health benefits, 401k match, and much more.  For more information about our plans for the future, and to be considered for this career opportunity, please visit




Contact: Elankovan Ponnampalam (
At JUST, we believe everyone deserves to eat well. We're searching faster and further, working with rural farmers, Michelin-starred chefs and world-class product developers to find tools in the plant kingdom that will make our food tastier and healthier.
Senior Process Engineer
About The Role 
As a Sr. Process Engineer, you will be a key member of our Process Sciences Team, responsible for the process development and the commercial scale up of innovative plant-based proteins. The engineer will be involved in both laboratory and pilot plant processing trials/testing, optimization of key process operating parameters from the lab to pilot plant scale, and technology transfer to manufacturing facilities.
• Identify, evaluate and implement relevant unit processes to successfully scale processes from lab to pilot & commercial scales.
• Design and manage pilot/commercial scale testing to optimize product quality and functionality.
• Design and managepilot/commercial scale testing to optimize process efficiency, yield & throughput.
• Understand and implement analytical testing to gather critical data. Interpret and present data in scientific reports.
• Develop mass balances, process flow diagrams P&IDs, SOPs & batch records.
• Work closely with Process Development/Food Science team to assess products, developing critical understandings of the products from both process and formulation changes.
• Integral role in the management of the R&D process from lab scale to pilot scale ensuring well defined system & testing protocols.
• Technical expert for downstream equipment & processing. Demonstrating a detailed understanding of all standard unit operations used in downstream protein separation & isolation.
• Equipment installation and project engineering, working with vendors, experience with plant utilities, automation & controls critical.
• Develop processes in compliance with appropriate food GMPs and applicable food safety standards.
• Assess safety procedures and policies, participate in HAZOP process.
• Feasibility and optimization studies. Implement processes at the lab-scale and then scale up to pilot plant level

About You

Education & Experience

• PhD. (7 years) or master’s degree (minimum 10 years) in Chemical Engineering, or Food Engineering with relevant food or bioproducts processing experience, P.E. preferred, 10 + years’ experience preferred;

• Demonstrated Hands-on experience in laboratory and pilot plant food or bioprocessing plant setting, working knowledge with protein recovery processes preferred;

• Experience in cGLP, cGMP, Sanitary 3-A, HAACP, OSHA, and other relevant FDA guidelines and norms for food production necessary;

Skills & Qualifications
• Technical Subject Matter Expert with hands-on in solids-liquids separation methods, liquid-handling methods, filtration, heat transfer, plant sourced feed material size reduction techniques and standard protein unit operations.
• Strong leadership experiences in technology transfer to CMOs, and preferably demonstrated project management skills;
• Knowledge of FDA guidelines for process validation is recommended;
• Good interpersonal and communication skills, strong organizational traits; team player;
• Able to pass a standard background check
Additional Information & Requirements
This is a full-time position. While there will be standard days and hours of work, the positions requires overnight on-call duty and the ability to work during nonstandard hours when the need arises.
In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire. Just, Inc. participates in E-Verify and will provide the Social Security Administration (SSA) and, if necessary, the Department of Homeland Security (DHS), with information from each new employee’s Form I-9 to confirm work authorization.


Fermentation Engineer at Culture Robotics


South San Francisco · Full Time
Culture Robotics grows organisms for biotech companies. We've built the first cloud bioreactor farm. Here’s how it works: our customers send us organisms. We grow them in our bioreactors according to specified recipes. And then we send back data and samples. Our customers genetically modify organisms to produce new therapeutics, materials, fuels, and foods. We help them quickly test their organisms and manufacturing processes so they can get their products to market faster. We've built proprietary software and automation systems to make operating our bioreactors more efficient than existing systems. 


Safety Basis Analyst

Lawrence Livermore National Laboratory

Date Posted: September 04 2018


Production Engineer- Antioch, CA

(616) 796-2281

Requirements to be considered for the proDUCTION engineering role:

·       B.S. in Chemical Engineering

·       2+ years’ production engineering experience in a chlor-alkali facility

·       Act as a technical resource for plant operations

Responsibilities OF THE PROduction ENGINEER:

·       Optimize plant performance

·       Understand EHS operational requirements

·       Maintain high standards for process safety


Very competitive.

Outstanding opportunity to have a tremendous impact and grow rapidly within an organization and would welcome the opportunity to provide more details over the phone.

If this specific opportunity does not meet your current needs, please help me in fulfilling my client’s need by forwarding this on to someone who fits the description; or, if you prefer anonymity, simply call or email your referral(s) to me. Thank you very much for your assistance in networking with me!  I look forward to my conversation with you and/or one of your colleagues!