Crabtree earned his B.S. in Chemistry and Mathematics from Western Liberty State College and his M.D. from Temple University. While at medical school, he became interested in laboratory research and started to work at Dartmouth College with Allan Munck on the biochemistry of steroid hormones. Studying gene regulation, he discovered hepatocyte nuclear factor 1 and started to focus on nuclear gene regulation.
After a short stint at the NIH, he started his lab at Stanford in 1985. Using T lymphocytes as a model system, he discovered the nuclear factor of activated T cells (NFAT).[2]...Read more