(489g) Drug-like Antibodies By Design and Directed Evolution (Invited Speaker)
AIChE Annual Meeting
2020
2020 Virtual AIChE Annual Meeting
Food, Pharmaceutical & Bioengineering Division
New Frontiers in Biomolecular Engineering
Thursday, November 19, 2020 - 9:30am to 9:45am
The biotech industry has seen an explosion in the development of therapeutic antibodies in the last decade, and today most of the best-selling drugs are monoclonal antibodies. The advantages of antibodies as therapeutics â namely their high affinity, specificity, potency, stability, manufacturability and low toxicity â are compelling. Nevertheless, there are many fundamental challenges associated with antibody discovery and development that require key technical advances in order to improve the rational generation of potent antibody therapeutics. I will discuss our progress in addressing some of these challenges, including the design, evolution, selection and characterization of drug-like antibodies with high affinity, specificity, stability and solubility.