Advantages and Limitations of Single-Use Systems in Downstream Processing

Pharmaceutical Discovery, Development and Manufacturing Forum
AIChE Annual Meeting
November 7, 2013 - 5:20pm-5:45pm
Biopharmaceutical downstream processes are generally dominated by chromatographic separations and membrane filtrations. Single-use systems can increase the efficiency and reduce the costs of these processes , but there are limitations. A common target for single use technology is the preparation , holding and distribution of the numerous buffer solutions required in downstream processing. Buffer preparation may become a capacity-limiting process (bottleneck) in certain high-capacity situations. This paper examines the use of macroscopic modeling techniques to evaluate buffer preparation for downstream processing.  A series of cases studies are based on downstream processing for a 2000 L mammalian cell-culture process. Single use buffers offered a number of advantages including  a 34% savings in capital costs , a 20% reduction in purified water usage , up to 20% reduction in unit and potential throughput advantages. The cost advantages decline with increased protein load on the process. Furthermore ,  this study explores facility floor-space limitations that become important when large numbers of disposable containers need to be managed.
Professional Development Hours
0.5 PDHs
You will be able to download and print a certificate for these PDH credits once the content has been viewed. If you have already viewed this content, please click here to login.
Presenter(s): 

Would you like to access this content?

No problem. You just have to complete the following steps.

You have completed 0 of 2 steps.

  1. Log in

    You must be logged in to view this content. Log in now.

  2. Purchase Technical Presentation

    You must purchase this technical presentation using one of the options below.
    If you already purchased this content recently, please click here to refresh the system's record of ownerships.

Pricing

Credits 0.5 Use credits
List Price $25.00 Buy now
AIChE Members $15.00 Buy now
AIChE Undergraduate Student Members Free Free access
AIChE Graduate Student Members Free Free access
Related Topics: