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Advantages and Limitations of Single-Use Systems in Downstream Processing

Developed by: AIChE
  • Type:
    Conference Presentation
  • Conference Type:
    AIChE Annual Meeting
  • Presentation Date:
    November 7, 2013
  • Duration:
    30 minutes
  • Skill Level:
    Intermediate
  • PDHs:
    0.50

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Biopharmaceutical downstream processes are generally dominated by chromatographic separations and membrane filtrations. Single-use systems can increase the efficiency and reduce the costs of these processes , but there are limitations. A common target for single use technology is the preparation , holding and distribution of the numerous buffer solutions required in downstream processing. Buffer preparation may become a capacity-limiting process (bottleneck) in certain high-capacity situations. This paper examines the use of macroscopic modeling techniques to evaluate buffer preparation for downstream processing.  A series of cases studies are based on downstream processing for a 2000 L mammalian cell-culture process. Single use buffers offered a number of advantages including  a 34% savings in capital costs , a 20% reduction in purified water usage , up to 20% reduction in unit and potential throughput advantages. The cost advantages decline with increased protein load on the process. Furthermore ,  this study explores facility floor-space limitations that become important when large numbers of disposable containers need to be managed.

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