A new method of gene editing that combines the defenses of bacteria with the weapons of viruses can snip out and replace entire genes rather than correcting individual mutations.
The method, which researchers have dubbed “programmable addition via site-specific targeting elements” (PASTE), could be promising for genetic disorders — such as cystic fibrosis — caused by hundreds or thousands of mutations to a gene. Other methods of gene editing can be used to correct such mutations, but either only work in dividing cells, not mature (quiescent) cells, or can introduce new errors when they cut the DNA strands to insert the new sequences.
Many gene-editing methods struggle to deliver long genetic sequences. Since some genes are tens of thousands of individual genetic bases long, this limitation forces researchers to pick a short disease-causing mutation in a gene to fix. Researchers typically pick the most common mutations to target, leaving patients with less-common mutations behind, says Omar Abudayyeh, a McGovern Fellow at the Massachusetts Institute of Technology’s (MIT’s) McGovern Institute for Brain Research...
Would you like to access the complete CEP News Update?
No problem. You just have to complete the following steps.
You have completed 0 of 2 steps.
You must be logged in to view this content. Log in now.
You must be an AIChE member to view this article. Join now.
Would you like to reuse content from CEP Magazine? It’s easy to request permission to reuse content. Simply click here to connect instantly to licensing services, where you can choose from a list of options regarding how you would like to reuse the desired content and complete the transaction.