CRISPR-Based Tool Detects Viral DNA

March
2018

A team of scientists led by Jennifer Doudna, a professor of biochemistry and molecular biology at the Univ. of California, Berkeley, has created a new DNA detection system based on CRISPR biology.

The new system, which the researchers have termed DNA endonuclease targeted CRISPR trans reporter (DETECTR), enabled rapid detection of human papillomavirus (HPV) in patient samples. The team believes DETECTR could serve as a simple platform for molecular diagnostics in the near future.

CRISPR are segments of DNA that contain repetitive base sequences, which are critical to CRISPR-Cas antiviral defense systems in bacteria. In previous studies, scientists discovered that the endonuclease enzyme, Cas9, can be programmed with customized guide RNA (gRNA) to recognize virtually any DNA sequence. The gRNA...

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