Troubleshooting Tangential Flow Filtration

June
2003

Tangential flow filtration (TFF) is commonly used to concentrate and dialyze solutes. It generally involves the circulation of the feed solution over a filter surface. This article presents a brief overview of the principles governing TFF, and offers an empirical approach to optimizing operating conditions for mammalian cell-culture clarification applications. clarification, this optimization is complicated by the fact that the cells are damaged by high feed flowrates.

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