Application of Modeling to Scale-up Liquid Mixing Processes | AIChE

Application of Modeling to Scale-up Liquid Mixing Processes


Conference Presentation

Conference Type

AIChE Annual Meeting

Presentation Date

November 11, 2009

Skill Level




Scale-up of liquid mixing is usually done empirically without considering the several factors like dissolution theory, equipment differences between scales and so on. In this work we present a systematic way to scale-up liquid mixing processes utilizing both Design of Experiment (DoE) approach to identify the operating space (effect of operating parameters) and Computational Fluid Dynamics modeling to scale the mixing dynamics from laboratory to commercial scale. Underlying principles of modeling and also experimental data on dissolution at different scales for model solutes will be presented. This work also serves as an example of utilizing Quality by Design principles in designing the operating space during drug product manufacturing process design.&'


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