PD2M Workshop of Reaction Engineering in the Pharmaceutical Industry | AIChE

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PD2M Workshop of Reaction Engineering in the Pharmaceutical Industry

Wednesday May 10 2023

9:00 - 9:15 AM   Opening Remarks  
Session 1: Trends in Reaction Engineering using Artificial Intelligence and Machine Learning
9:15 - 11:30 AM Chair Ryan Hartman  
  9:15-10:00AM Reaction engineering, ML, and automation for chemical discovery and development Klavs Jensen (MIT)
  10:00-10:30 AM Autonomous, Algorithmic Process Optimization in the Mettler Toledo AutoChem Ecosystem Keith Mattern (Merck)
  10:30-11:00 AM Coupling reaction engineering with data-rich experimentation to guide the impurity control strategy for CELMoD API reactions Geoff Purdum (BMS)
  11:00-11:30 AM Panel Discussion  
11:30 AM- 12:30PM Lunch    
Session 2: Reaction Engineering in Process Intensification
12:30 - 3:15 PM Chair Jon McMullen  
  12:30-1:15PM Flexible Automation Enables Autonomous Process Optimization Jason Hein (U. British Columbia)
  1:15-1:45PM Leveraging Small Data for Faster Optimization and Enhanced Results in Pharmaceutical Development Daniela Blanco (Sunthetics)
  1:45-2:15 PM Doing more with less: Value of Process Intensification Techniques for Small Molecule Synthesis Jayachandran Devaraj (Corteva)
  2:15-2:45PM Tracking lot genealogy in continuous drug substance manufacturing processes through mechanistic modeling     Dana Barrasso (Siemens)
3:15- 3:30PM Break    
Session 3: Next Practices in Transport and Novel catalyses
3:30 - 6:15 PM Chair Marty Johnson  
  3:30-4:15PM Novel Batch and Continuous Syntheses of the HIV Integrase Inhibitor, Dolutegravir Thomas Roper (Virginia Commonwealth University)
  4:15-4:45 PM Challenges and opportunities in emerging reaction technologies in pharmaceutical development with a focus on photochemistry scale-up Melda Sezen Edmonds (BMS)
  4:45-5:15 PM Photochemical process design, scale-up, and manufacturing Kevin Nagy (Snapdragon)
  5:15-5:45 PM Process Development and Scale-up of a Photochemical Reaction for Drug Substance Manufacturing Jon McMullen (Merck)
  5:45-6:15 PM Evolution of a platform for aerobic processes Joe Martinelli (Eli Lilly)
6:15 - 7:30 PM Reception    

Thursday May 11 2023

8:00 - 9:00 AM Breakfast    
Session 4: New Frontiers in Atypical Reactors and Reactor Design
9:00 - 11:45 AM Chair Andy Bommarius    
  9:00-9:45AM Continuous Reactors for API Manufacturing Martin D. Johnson ( Eli Lilly)
  9:45-10:15 AM A CDMO Perspective on Continuous Processing Scale-Up: Solving Process Development Challenges using Flexible Equipment Designs and Reaction Modelling Ryan Woods (AMPAC Fine Chemicals)
  10:15-10:30 AM Break  
  10:30-11:00AM Criteria for selection of continuous reactor and approach to scale-up in API pilot plant for multi kilo production Onkar Manjrekar (Abbvie)
  11:00-11:30 AM First-Principle Models for Process Monitoring and Risk Assessment in Continuous Pharmaceutical Syntheses Neda Nazemifard (Takeda)
  11:30AM-12:00PM Food for Thought - Unusual Sources of Inspiration for Reactor Designs Luke Rogers (On Demand Pharma)
12:00PM- 1:00PM Lunch    
Session 5: Future of Pharmaceutical Reaction Engineering
1:00 - 3:30 PM Chair Moiz Diwan  
  1:00-1:45PM Data-Centric Intensification of the Laboratory for the Development of Mechanisms Ryan Hartman (NYU)
  1:45-2:15 PM Scaleup Considerations for Solid-Phase Peptide Synthesis in Highly Dynamic Packed Beds Harrison Rose (Merck)
  2:15-2:45PM Utilizing Online LCMS to Improve the Development of Solid-Phase Peptide Synthesis (SPPS) Mark Berglund (Eli Lilly)
  2:45-3:15PM Development and Application of High-Throughput Experimentation to Guide Scalable Flow Syntheses of NCE and API David Thompson (Purdue)
  3:15-3:45PM Mechanistic Modeling of in-Vitro Transcription for mRNA Production     Nathan Stover (MIT)
3:45-4:00PM Closing remarks    

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