2020 Danckwerts Lecture | AIChE

2020 Danckwerts Lecture

  • Monday, November 16 - PST

    Hilton San Francisco Union Square
  • The Executive Editors of Chemical Engineering Science and the members of the selection committee are pleased to announce the 2020 Danckwerts Lecture will be presented by Dr. Massimo Morbidelli. 

    The P. V. Danckwerts Lecture was established in 1985 to honor Prof. Peter V. Danckwerts as a leading scholar in the field of chemical engineering, former Chairman of the Board of Chemical Engineering Science, and the past President of IChemE.  The Danckwerts Lecture is co-sponsored by Elsevier, AIChE, IChemE, and EFCE and is held in alternating years at the ECCE and AIChE meetings.

    Integration and Digitalization in the Manufacturing of Therapeutic Proteins

    Massimo Morbidelli

    Dipartimento di Chimica, Materiali e Ingegneria Chimica

    Politecnico di Milano, Milano, Italy

    Increasing costs and time pressure, as well as diversifying pipelines asking for more flexible production concepts and better product safety and efficacy, are driving the biopharmaceutical industry towards continuous and integrated manufacturing. However, we are still far from an efficient implementation of such technologies. The full exploitation of their potential requires significant advances in process digitalization for online monitoring, control, optimizazion and maintenance. 

    In particular, we consider hybrid approaches, where statistical methods based on machine learning techniques are used online in combination with ad-hoc mechanistic models. As an experimental basis for discussion, we take an automated end-to-end integrated platform for the production of a monovalent monoclonal antibody of industrial relevance. The process consists of a perfusion bioreactor, a continuous protein A capture step, followed by low-pH virus inactivation, and frontal and flow-through chromatographic steps for final polishing. 

    Applications include: development of soft sensors for up and down stream monitoring (Raman based), the hierarchical online process control and optimization of a capture twin columns unit and online maintenance (replacement of protein A based stationary phase in a monoclonal antibody capture process).

    We discuss the need for an efficient centralized process data collection and hierarchical control system, firmly based on hybrid algorithms, to allow continuous integrated manufacturing of biopharmaceuticals to develop and grow in agreement with the trends of industry 4.0.