(344a) Assessing the Adequacy of a Sampling Frequency in the Application of PAT to a Continuous Manufacturing Process for Drug Product
- Conference: AIChE Annual Meeting
- Year: 2017
- Proceeding: 2017 AIChE Annual Meeting
- Group: Pharmaceutical Discovery, Development and Manufacturing Forum
Tuesday, October 31, 2017 - 12:30pm-12:52pm
Our contribution will discuss a hybrid approach that uses information from a deterministic model, and the variability in the NIR spectra, along with time-series analysis techniques (such as ARX models, partial auto correlation coefficients, and cross-correlation coefficients) and the Shannon theorem of sampling to assess the adequacy of proposed frequencies of sampling and averaging in the spectrometer located in the feed-frame of the tablet press.