Paul Freemont

Paul Freemont

Professor, Chair in Protein Crystallography
Imperial College London

Professor Freemont is Head of the new Section of Structural Biology in the Department of Medicine at Imperial College. He is also co-founder and co-director of the EPSRC Centre for Synthetic Biology and Innovation and the National UK Innovation and Knowledge Centre for Synthetic Biology at Imperial College London. His interdisciplinary research has lead to the identification and naming of the RING finger domain found in many disease-linked human proteins and is associated with the global regulation of protein degradation. He has also determined a number of important crystal structures including the human DNA repair enzyme Ape-1, XRCC1 BRCT domain, procine spasmolytic polypeptide, and the human disease associated ATPase p97. In addition his laboratory has a strong interest in nuclear cell biology, driven by his co-discovery of SUMO-1 a post-translational modification protein associated with global protein regulation. He has also developed new quantitative approaches to aid the understanding of  nuclear organisation. His more recent research interests in the field of synthetic biology have focused on developing foundational technologies and the developement of biosensors for healthcare applications.