May 2012 | AIChE

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May 2012

Gene Regulation by MAPK Substrate Competition

Conference Presentation
AIChE Annual Meeting
November 9, 2010
Introduction Traditional view of pattern formation in the early Drosophila embryo is essentially one-dimensional: The anterior, posterior, and...

Modeling and Analysis of the Retinoic Acid Induced Proliferation and Differentiation Program of HL-60

Conference Presentation
AIChE Annual Meeting
November 9, 2010
Understanding the molecular basis of differentiation programs is one of the grand unmet challenges facing modern cell-biology. In this study, we...

Stochastic Simulations of the Tetracycline Operon

Conference Presentation
AIChE Annual Meeting
November 9, 2010
The tetracycline (tet) operon is a robust self-regulated system. It is found naturally in bacteria where it confers resistance to antibiotic...

Identification of Cell-Type Specific Transcripts for Informative Diagnostics

Conference Presentation
AIChE Annual Meeting
November 8, 2010
The identification of cell-type specific or brain-region specific transcripts adds specificity for the diagnosis of a wide variety of brain disorders...

Quantitative Modeling and Analysis of TGF-ß-Induced Erk/MAPK and Smad Signaling

Conference Presentation
AIChE Annual Meeting
November 9, 2010
Transforming growth factor ß (TGF-ß), which plays a pivotal role in regulating a wide array of cellular and physiologic processes in both...

Gene Expression Profiling of Short- and Long-Term Changes in Rat Liver Following Burn Injury and CLP Treatment

Conference Presentation
AIChE Annual Meeting
November 8, 2010
An important player in systemic hypermetabolism is the liver, which generally controls circulating levels of metabolites. It is well known that the...

Comprehensive Analysis of Liver Transcriptome Reveals Distinct Disease Signatures

Conference Presentation
AIChE Annual Meeting
November 8, 2010
Major liver diseases such as hepatocellular carcinoma, cirrhosis, and hepatitis affect huge numbers of people. For example, each year, death from...

Directed Evolution of Quorum-Sensing Dependent Transcriptional Repressors for Programmed Intercellular Communication

Conference Presentation
AIChE Annual Meeting
November 7, 2010
One of the key challenges in the field of synthetic biology is to engineer not only single cells but also communities of cells that exhibit...

Probabilistic Integrative Modeling of Genome-Scale Metabolic and Regulatory Networks in Escherichia Coli and Mycobacterium Tuberculosis

Conference Presentation
AIChE Annual Meeting
November 9, 2010
Systems biology seeks to understand the cell by studying interactions between its various components and the properties that emerge from these...

Multiscale Modeling and Analysis of TRPV1 Regulation in Sensory Neurons

Conference Presentation
AIChE Annual Meeting
November 8, 2010
TRPV1 (transient receptor potential vanilloid subtype 1) receptors play a central role in nociception and inflammatory pain. Interestingly, both...

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