(267i) A Detailed Comparison of Comparison of Traditional Pan Coating to Novel Consigma Tablet Coating
AIChE Annual Meeting
Thursday, November 18, 2021 - 11:15am to 11:30am
Computational methods are increasingly used in the pharmaceutical industry as well and facilitate a deeper understanding of the process mechanics. The discrete element method (DEM) and computational fluid dynamics (CFD) are two methods that allow the transition from empirical process design to a mechanistic understanding of the individual process units. This work used CFD-DEM simulations to compare a laboratory batch coating process to the coating process inside the ConsiGma tablet coater.
The goal of this work is to present a comprehensive overview of the similarities and differences between the two coating processes. For both coaters, a small design of experiments is performed. The simulations are analyzed for the temperature and coating mass / liquid distribution, forces acting on the tablets during the coating process, cycle time, spray residence time, and spray mass per spray zone visit. The results give a comprehensive overview of the similarities and differences in both coating process types and should simplify the scaling between the two. This work can help accelerate the scale between the two coater types