Next-generation DNA sequencing techniques have both revolutionized the field of genetics and introduced a new set of challenging bioinformatics problems. These new methods carry out a massive number of sequencing operations in parallel and read hundreds of billions of base pairs per run. (A base pair is a pair of nucleotides, either guanine-cytosine or adenine-thymine.) By comparison, the classical sequencing method (developed by British Nobel Laureate Frederick Sanger) that was used for the original human genome project produced approximately a hundred thousand base pairs of data in its optimized form — a difference of six orders of magnitude.
Would you like to access the complete CEP Article?
No problem. You just have to complete the following steps.
You have completed 0 of 2 steps.
Would you like to reuse content from CEP Magazine? It’s easy to request permission to reuse content. Simply click here to connect instantly to licensing services, where you can choose from a list of options regarding how you would like to reuse the desired content and complete the transaction.